interleukin-11

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interleukin-11

[‚in·tər¦lük·ən i′lev·ən]
(immunology)
A pleiotropic cytokine produced by bone marrow-derived fibroblasts which supports the growth of certain cell types, such as B cells, neutrophils, and platelet-producing megakaryocytes. Abbreviated IL-11.
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2] Relatively recent studies have shown that human melanoma and breast cancer cells can induce bone resorption in a murine calvaria culture system through both the direct elaboration of interleukin 11 (IL-11) and by enhancing its production via the activation of the latent transforming growth factor [Beta] (TGF-[Beta])[3,4]; therefore, it was hypothesized that these 2 cytokines may be involved in the pathogenesis of the osteolytic lesions in LCH.