interleukin-12

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interleukin-12

[‚in·tər¦lük·ən ′twelv]
(immunology)
A heterodimeric cytokine that stimulates nonspecific cytotoxic natural killer-type cells to produce gamma interferon. Abbreviated IL-12.
References in periodicals archive ?
In vitro analysis demonstrated that LMS is synergistic with interleukin 12 in the induction of a Th1 cytokine response at very low concentrations (1microM).
The drug was developed to inhibit elements of the body's immune system, Interleukin 12 and Interleukin 23.
1) One of the proteins investigated was Interleukin 12 (IL-12).
Ustekinumab is a novel biologic therapy that targets interleukin 12 (IL-12) and interleukin 23 (IL-23), naturally occurring proteins that are important in regulating the immune system and that are also believed to play a role in immune-mediated inflammatory disorders.
Low penetrance, broad resistance, and favourable outcome of interleukin 12 receptor [beta] 1 deficiency: medical and immunogical implications.
Specifically, the company has elucidated that tetragenococcus halophilus Th221, a kind of plant-derived lactic acid bacteria found in soy sauce, can induce the generation of interleukin 12 (IL-12), a substance that helps alleviate allergic symptoms.
Gene therapy using interleukin 12 (IL-12) is an effective treatment for graft- versus-host disease (GVHD) in mice, according to a study by Japanese researchers.
Researchers began testing the immune messenger interleukin 12 to treat several diseases (146: 120).
Since its launch, the uptake of the interleukin 12 and 23 (IL-12/23) inhibitor Stelara has been cautious, owing to a limited long-term safety record and physicians' unfamiliarity with the drug's mechanism of action.
People who have a genetic problem where the body does not make any of the proteins interleukin 12 (ILCE12) and interleukin 23 (ILCE23) are at a higher risk for certain serious infections that can spread throughout the body and cause death.
Specifically, the Laboratory has confirmed that L-92 can induce interleukin 12 (IL-12) and inhibit the excessive activity of Th2 immune cells.
LSF improves cellular mitochondrial function and blocks interleukin 12 (IL-12) signaling and STAT-4 activation in target cells and tissues.