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Isocitric Acid
(redirected from Isocitrate)

    Also found in: Medical, Wikipedia 0.03 sec.
isocitric acid [¦ī·sə¦si·trik ′as·əd]
(biochemistry)
HOOCCH2CH(COOH)CH(OH)COOH An isomer of citric acid that is involved in the Krebs tricarboxylic acid cycle in bacteria and plants.
Isocitric Acid 

an organic tricarboxylic acid; one of the intermediate substrates of the tricarboxylic acid cycle.

Isocitric acid forms in an organism from citric acid and cisaconitic acid as a result of enzymatic conversion. With involvement of the enzyme isocitrate dehydrogenase, isocitric acid is converted, through oxalosuccinic acid, to α-ketoglutaric acid. With the aid of the enzyme isocitratelyase in the glyoxalate cycle, isocitric acid decomposes to succinic and glyoxylic acids.
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Glucose-6-phosphate dehydrogenase and isocitrate dehydrogenase, which provide reduced nicotinamide adenine dinucleotide phosphate (NADPH), also showed higher activity in the epidermis than the dermis by 111% and 313%, respectively.
Enzymic and non-enzymic antioxidants in epidermis and dermis of human ... by Life Extension
Mitochondrial aconitase is the enzyme responsible for the isomerization of citrate to isocitrate in the tricarboxylic acid (TCA) cycle.
Structural studies of human mitochondrial aconitase by Journal of the Alabama Academy of Science
net/cgi-bin/mlst7/ index) uses PCR primers to amplify internal segments of 7 specific housekeeping genes (aspartate aminotransferase [aspC], caseinolytic protease [clpX], acyl-CoA synthetase [fadD], isocitrate dehydrogenase [icdA], lysine permease [lysP], malate dehydrogenase [mdh] and uidA), which are purified and sequenced.
Genetic diversity among clonal lineages within Escherichia coli ... by Feng, Peter C.H.; Monday, Steven R.; Lacher, David W.; Allison Lesley; Siitonen, Anja; Keys, Christi / Emerging Infectious Diseases
 
 
 
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