Isoquinoline


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isoquinoline

[¦ī·sə′kwin·ə‚lēn]
(organic chemistry)
C6H4CHNCHCH Colorless liquid boiling at 243°C; soluble in most organic solvents and dilute mineral acids, insoluble in water; derived from coal tar or made synthetically; used to make dyes, insecticides, pharmaceuticals, and rubber accelerators, and as a chemical intermediate.

Isoquinoline

 

colorless crystals with a faint odor of almonds. Melting point, 24.5°C, and boiling point, 243°C. Its structural formula is

Slightly soluble in cold water, isoquinoline dissolves readily in organic solvents. It is present in low concentration in coal tar, from which it is separated with quinoline. Isoquinoline is a stronger base than quinoline. The most important method of preparing isoquinoline and its derivatives is by cyclodehydration of /3-phenylethylamides of acids C6H5CH2CH2NHCOR (the Bischler-Napieralski reaction) followed by dehydrogenation of the resultant 3, 4-dihydroisoquinolines. The isoquinoline nucleus is present in a number of important alkaloids, such as papaverine, morphine, codeine, and curarine.

References in periodicals archive ?
5) Compounds having the structure noncondensable pyridine ring or a quinoline or isoquinoline cycles without further condensation; lactams; other heterocyclic compounds only with nitrogen hetero (20.
Bioassay-guided fractionation of the methanol extract led to the isolation of several compounds, mainly isoquinoline alkaloids of the benzophenanthridine-type (Luo et al.
vulgaris which indicated that the most important constituents of this plant are isoquinoline alkaloids such as berbamine, palmatine and particularly berberine (10).
Berberine is an isoquinoline alkaloid found in numerous herbs including Hydrastis canadensis, Berberis aquifolium (syn.
In addition, isoquinoline, phenylpyridine, benzenedicarbonitriles and pyridinecarbonitriles can be considered as markers of 'black N' (BN) (Knicker 2007; Kaal et al.
Rackova L, Oblozinsky M, Kostalova D, Kettmann V and L Bezakova Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids.
Berberine, the major active component in Coptis Chinesis, is an isoquinoline derivative alkaloid that is widely used in the treatment of calf diarrhea (Liu et al.
99) The effects of Berberis species, and the isoquinoline alkaloid berberine in particular, have demonstrated in vitro effects against respiratory pathogens such as S.
The early steps of the morphine biosynthesis pathway leading from the primary metabolite tyrosine via the general isoquinoline pathway to the tetracyclic salutsridinol have been clarified both at the metabolite and the enzyme level [20].
Nickel(II) complexes based on combination of N-N ligands with 6,7-dimethoxy-1,2,3,4-tetrahydro isoquinoline or 3,4-dimethoxy pheneth-ylamine of the formulas [Ni(phen)(6,7,THIQ) [([H.
Their topics include genetic and cellular multiple drug resistance in a diagnostic and therapeutic strategy in acute leukemia in children and adults, herb-drug interactions and implication in drug monitoring, bacteriophage therapies and enzybiotics as novel solutions to antibiotic resistance, nutrition and tuberculosis, reversing multidrug resistance by the isoquinoline alkaloid glaucine, and finding the genetic solution for cancer in the mechanism of taxol cytotoxicity.