Isoquinoline

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isoquinoline

[¦ī·sə′kwin·ə‚lēn]
(organic chemistry)
C6H4CHNCHCH Colorless liquid boiling at 243°C; soluble in most organic solvents and dilute mineral acids, insoluble in water; derived from coal tar or made synthetically; used to make dyes, insecticides, pharmaceuticals, and rubber accelerators, and as a chemical intermediate.

Isoquinoline

 

colorless crystals with a faint odor of almonds. Melting point, 24.5°C, and boiling point, 243°C. Its structural formula is

Slightly soluble in cold water, isoquinoline dissolves readily in organic solvents. It is present in low concentration in coal tar, from which it is separated with quinoline. Isoquinoline is a stronger base than quinoline. The most important method of preparing isoquinoline and its derivatives is by cyclodehydration of /3-phenylethylamides of acids C6H5CH2CH2NHCOR (the Bischler-Napieralski reaction) followed by dehydrogenation of the resultant 3, 4-dihydroisoquinolines. The isoquinoline nucleus is present in a number of important alkaloids, such as papaverine, morphine, codeine, and curarine.

References in periodicals archive ?
Dopaminergic isoquinoline alkaloids from roots of Xylopia papuana.
Effects of various isoquinoline alkaloids on in vitro [sup.
1) are isoquinolines alkaloids isolated from different species of Amaryllidaceae.
In this work, the activity of four isoquinolines alkaloids isolated from Hippeastrum species was investigated through the assay of AChE activity developed by Ellman et al.
Isoquinoline alkaloids are a major group of pharmacologically important compounds, and some isoquinoline alkaloids demonstrated antimicrobial, antibacterial, antifungal, antitumor and other biological active properties (Nepali et al.
The isoquinoline N-oxide alkaloid, 1-hydroxymethyl-6,7-dimethoxyisoquinoline N-oxide (3) (yield, 0.
This proposal has been supported by the fact that recently several studies have proved that some isoquinoline alkaloids have affinity for D2 receptors.
Isoquinoline derivates isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats: unexploited anti-depressive (lead) products.
In this work, we tested the total alkaloid and ethanol extracts of nine different plants from Brazilian families which produce isoquinoline alkaloids, to determine their in vitro antiparasitic effect against L.
Keywords: Leishmaniasis; Chagas disease; Isoquinoline alkaloids; Trypanosoma cruzi; Leishmania chagasi