isosterism

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isosterism

[ī′säs·tə‚riz·əm]
(physical chemistry)
A similarity in the physical properties of ions, compounds, or elements, as a result of electron arrangements that are identical or similar.
References in periodicals archive ?
The bioisosteric replacement of oxygen by sulfur in chlorpromazine to give the oxygen isostere.
According to this concept, isosteres are those atoms or groups of atoms or molecules or compounds (organic or inorganic) that have the same arrangement and/or number of electrons that is isoelectronic or isosteric.
In the mid-1990s, Kool's group synthesized a non-hydrogen-bonded natural base pair analog between 4-methylbenzimidazole (Z) and 2,4-difluorotoluene (F), as a steric isostere of the A-T pair (Figs.
Since the Q base is an isostere of A, Q also pairs with T.
257) See Silverman, supra note 10, at 29 (listing fluorine (F) as an isostere of hydrogen (H)).
The analogs contain a hydroxyethylene isostere as a replacement for the amide bond.
OM99-2 is based on an octapeptide Glu-Val-Asn-Leu-Ala-Ala-Glu-Phe (SEQ ID NO:28) with the Leu-Ala peptide bond substituted by a transition-state isostere hydroxyethylene group (FIG.
Paradigm Therapeutics is exploiting the use of silicon as an isostere for carbon in drug design in cases where the presence of silicon could improve the molecule's properties.