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isosterism
(redirected from Isostere)

   Also found in: Wikipedia 0.01 sec.
isosterism [ī′säs·tə‚riz·əm]
(physical chemistry)
A similarity in the physical properties of ions, compounds, or elements, as a result of electron arrangements that are identical or similar.


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OM99-2 is based on an octapeptide Glu-Val-Asn-Leu-Ala-Ala-Glu-Phe (SEQ ID NO:28) with the Leu-Ala peptide bond substituted by a transition-state isostere hydroxyethylene group (FIG.
Paradigm Therapeutics is exploiting the use of silicon as an isostere for carbon in drug design in cases where the presence of silicon could improve the molecule's properties.
 
 
 
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