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Jak-STAT pathway

   Also found in: Wikipedia 0.01 sec.
Jak-STAT pathway [′jak‚stat ′path‚wā]
(cell and molecular biology)
A rapid signal transduction pathway used by a variety of cytokines and growth factors to alter gene expression. Binding of a cytokine or growth factor to its receptor activates Jak (janus kinase—a cytoplasmic tyrosine kinase) and triggers it to phosphorylate and stimulate STAT (signal transducers and activators of transcription—a gene regulatory protein) to travel to the nucleus and induce transcription of a specific gene.
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Their topics include the role of toll-like receptors in the inmate immune response to RNA viruses, mitochondrial antiviral signaling, the Jak-Stat pathway in response to virus infection, interferons and antiviral action, and human genetic factors involved in viral pathogenesis.
Cellular signaling and innate immune responses to RNA virus infections by SciTech Book News
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes.
G-CSF in acute myocardial infarction--experimental and clinical ... by Akar, Ahmet Ruchan; Durdu, Serkan; Topcuoglu, Pervin; Ince, Huseyin; Petzsch, Michael; Rehders, Tim / The Anatolian Journal of Cardiology (Anadolu Kardiyoloji Dergisi)
Kotecha knew that GM-CSF activates a particular cellular signaling cascade called the JAK-STAT pathway.
New Stanford Diagnostic Test for Rare Leukemia Appears to Give Faster ... by Business Wire
 
 
 
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