The results could mean "that inhibition of the JAK-STAT pathway
may be a new therapeutic target for AD," wrote the study's lead author, Robert Bissonnette, MD, president of Innovaderm Research in Montreal (Br J Dermatol.
Progression of liver disease can be controlled by a number of cellular mediators among which JAK-STAT pathway
plays a significant role.
Several of these newly discovered mutations raise the possibility of targeting subpopulations of JMML cases with existing drugs: Janus kinase (JAK) inhibitors, currently used to treat certain other bone marrow and blood cancers such as polycythemia vera, might inhibit signaling through a hyperactive JAK-STAT pathway
identified in some patients, while other agents such as 5-azacytidine, most commonly used as a treatment for a blood disorder known as myelodysplastic syndrome, could be used to reduce excessive epigenetic DNA methylation seen in others.
Type Iii interferon (Ifn) induces A Type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-Stat pathway
and the mitogen-activated protein kinases.
By targeting the JAK-STAT pathway
which is dysregulated in myelofibrosis, Jakavi(R) delivers a rapid and durable benefit that has the potential to make a real difference in the lives of patients with
phagocytophilum at low levels by downregulating some adaptive immune genes and delaying the apoptotic death of neutrophils through activation of the Jak-STAT pathway
, among other mechanisms (6), their role as a source of infection for ticks remains to be demonstrated.
Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway
Their topics include the role of toll-like receptors in the inmate immune response to RNA viruses, mitochondrial antiviral signaling, the Jak-Stat pathway
in response to virus infection, interferons and antiviral action, and human genetic factors involved in viral pathogenesis.
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway
Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway