Jak-STAT pathway

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Jak-STAT pathway

[′jak‚stat ′path‚wā]
(cell and molecular biology)
A rapid signal transduction pathway used by a variety of cytokines and growth factors to alter gene expression. Binding of a cytokine or growth factor to its receptor activates Jak (janus kinase—a cytoplasmic tyrosine kinase) and triggers it to phosphorylate and stimulate STAT (signal transducers and activators of transcription—a gene regulatory protein) to travel to the nucleus and induce transcription of a specific gene.
References in periodicals archive ?
There are today 317 companies plus partners developing 433 Jak-STAT signaling pathway targeting drugs in 1172 developmental projects in cancer.
This Drug Pipeline Update contains 433 Jak-STAT signaling pathway targeting drugs in development, which have a total of 1172 developmental projects in cancer.
The JAK-STAT signaling pathway transmits information from chemical signals outside the cell, through the cell membrane, and into gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell (4).
Chemokine signaling pathway, cytokine-cytokine receptor interaction, and the JAK-STAT signaling pathway represented more than 50% of up-regulated transcripts in TCDD-treated and PCB-126-treated cells (Figure 1 A, B).
Evidence also suggests that A[beta] inhibits the JAK-STAT signaling pathway, thus potentially inhibiting IGF-1 expression.
These gene mutations result in stable activation of the JAK-STAT signaling pathway and lead to megakaryocytic hyperplasia and thrombocytosis.