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Köhler, Georges Jean Franz

   Also found in: Hutchinson 0.04 sec.
Köhler, Georges Jean Franz (kō`lər, Ger. kö`lər), 1946–95, German immunologist, Ph.D. Univ. of Freiburg, 1974. He worked (1974–76) with César Milstein Milstein, César, 1927–2002, Anglo-Argentine immunologist, Ph.D. Cambridge Univ., 1960. He worked (1961–63) at the National Institute of Microbiology, Buenos Aires, but following a military coup he resigned and returned to Cambridge, where he joined
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 at the Laboratory of Molecular Biology in Cambridge, England. There they developed a practical technique for mass-producing monoclonal antibodies monoclonal antibody, an antibody that is mass produced in the laboratory from a single clone and that recognizes only one antigen. Monoclonal antibodies are typically made by fusing a normally short-lived, antibody-producing B cell (see immunity ) to a fast-growing
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 by fusing antibody-producing cells with fast-growing cells, such as cancer cells. Their technique for antibody production has since been universally adopted, and the antibodies are used in diagnostics and in fighting leukemia. In 1984 he became a director of the Max Planck Institute of Immune Biology in Freiburg and, with Milstein and Niels K. Jerne Jerne, Niels Kai (nēls kī yĕr`nə), 1911–94, British-Danish immunologist, b. London.
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, shared the Nobel Prize in Physiology or Medicine.

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