Kanamycin


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Related to Kanamycin: chloramphenicol, Kanamycin sulfate

kanamycin

[‚kan·ə′mīs·ən]
(microbiology)
C18H36O11N4 A water-soluble, basic antibiotic produced by strains of Streptomyces kanamyceticus; the sulfate salt is effective in infections caused by gram-negative bacteria.

Kanamycin

 

(Kantrex, Resistomycin), an antibiotic of the amino glycoside group.

Kanamycin was first obtained from the actinomycete Strep-tomyces kanamyceticus in 1957. It is soluble in water, thermostable, and polybasic. Kanamycin is effective against most gram-negative and gram-positive bacteria and mycobacteria. It is ineffective against yeasts, fungi, enterococci, and bacteroids. Kanamycin sulfate solution is administered intramuscularly in the treatment of tuberculosis. Although kanamycin has a low level of toxicity, in large doses it produces side effects on the kidneys and acoustic nerves.

References in periodicals archive ?
About twenty randomly selected colonies were picked up containing pQE 501 clones and grown on LB broth containing Ampicillin and Kanamycin and incubated at 37[degrees]C overnight in a shaker incubator at 180 rpm.
Comparison of bactericidal activities of streptomycin, amikacin, kanamycin, and capreomycin against Mycobacterium avium and M.
3: Sites of modification of kanamycin B by aminoglycoside-modifying enzymes.
Regeneration was completely arrested at 150 mg/L kanamycin and 350 mg/L streptomycin but spectinomycin failed to arrest the regeneration.
coli competent cells were transformed with the ligation mixtures and the transformants were selected on LB agar plates containing 25 g/ml kanamycin (16).
All three bacterial strains showed different degrees of sensitivity against kanamycin, erythromycin, streptomycin, oxytetracyclin and neomycin but all strains were resistant against bacitracin (Table II).
The creatinase expression was done in LB broth medium containing kanamycin (50 [micro]g/ml) at 37 [degrees]C with 1 mM IPTG for two different times, 4 hr and overnight.
In order to obtain the optimal kanamycin concentration for selection of transformants, cotyledonary nodes of cucumber were placed on MS medium supplemented with 2.
It has proven a clear association of Ototoxicity with the use of Kanamycin and other aminoglycosides.