Kaposi's sarcoma


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Kaposi's sarcoma

(käp`əshē', kəpō`sē), a usually fatal cancer that was considered rare until its appearance in AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
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 patients. First described by an Austro-Hungarian physician, Moritz Kaposi, in 1872, it appears in three forms and is characterized by vascular skin tumors. Kaposi's sarcoma is endemic in Africa, where it is more aggressive, seen in children and young men, and accounts for 10% of malignancies in Congo (Kinshasa) and Uganda. A mild form of the disease is sometimes seen in elderly men of Mediterranean origin. The development of AIDS-related Kaposi's sarcoma has been linked to a virus of the herpes group. In the early 1980s it was seen in nearly 50% of AIDS patients, but the proportion has decreased since that time. In AIDS, Kaposi's presents as barely raised pink or red papules or plaques that become widely disseminated on the skin and in the gastrointestinal and respiratory tracts, where they may cause extensive bleeding. Treatment includes chemotherapy or surgical excision, cryosurgury (destruction by freezing), or electrodessication (destruction by heat). Local radiation therapy can also be effective. AIDS patients are treated with Vinblastine, an active, but weak, agent, which further lowers immunity.

Kaposi's sarcoma

[kə′pō·sēz sär′kōm·ə]
(medicine)
A multifocal malignant or benign neoplasm that occurs in the skin and sometimes in lymph nodes or viscera and is composed of primitive tissue that is involved in blood vessel formation.
References in periodicals archive ?
Larbre JP, Nicolas JE Collet P, Larbre B, Llorca G: Kaposi's sarcoma in a patient with rheumatoid arthritis possible responsibility of captopril in the development of lesions.
Expression and cytokine regulation of glucocorticoid receptors in Kaposi's sarcoma.
Progressive changes of Kaposi's sarcoma of the gingiva and palate.
Interferon Alfa-2a (Roferon-A), Schering-Plough Approved November 21, 1988 for the treatment of AIDS-related Kaposi's sarcoma in selected patients.
A snapshot of the global therapeutic scenario for AIDS - Related Kaposi's Sarcoma.
com/treatment/2015/02/24/could-cannabis-treat-hiv) is the second article featured in a leading HIV media venue on research that has been published by leading academic institutions on investigations of the utility of cannabinoids as safe and cost-effective treatments for Kaposi's sarcoma and HIV-driven inflammation, highlighting Cannabis Science's clinical research programs (see Cannabinoids as Treatment).
Kaposi's sarcoma (KS) differs from most other tumours in a number of important ways, and the needs and tools available for imaging differ as well.
In contrast, the incidence of Kaposi's sarcoma (also causally related to infection with HHV-8) is greater in men, and has decreased with improved immune function and HAART availability.
2) Dunkel et al reported in 1989 that alkyl nitrites have been demonstrated to be mutagenic in bacteria and that male homosexuals with Kaposi's sarcoma were also heavy users of nitrites.
The most common tumors that occur in AIDS, AIDS-related Kaposi's sarcoma (KS) and AIDS-related non-Hodgkin's lymphoma (ARL), provide models that illustrate the various issues and highlight the available clinical science findings on which to base a treatment plan for individuals with cancer and HIV/AIDS.