1) Subsequently, the term fetal thrombotic vasculopathy (FTV) was reserved for groups with 15 or more affected terminal villi per section (at least 2), revealing avascular villous morphology or villous stromal karyorrhexis
Genetic damage evaluation, mutation and genetic instability can be used as a biomarker to assess the level of lesion,  karyorrhexis
(KR) and binucleated eggs (BN) (Fig.
Cellular debris of necrotic beta cells appeared as eosinophilic smudges and necrotic changes in nuclei like pyknosis, karyolysis and karyorrhexis
Figure 2d showed a mouse treated with acetaminophen with extensive centrilobular necrosis, hydropic degeneration of hepatocytes, destruction of central vein endothelium, karyolysis, pyknosis, and karyorrhexis
However the group that received 156 mg/kg of the extract also showed evidences of karyorrhexis
However, the hippocampal neurons in the model group exhibited clear pyknosis, nuclear invagination, karyorrhexis
and increased numbers of lysosomes.
H&E stained sections of the STZ-induced diabetic group showed myocardial disarray accompanied with loss of the normal striated architecture of the cardiomyocytes with presence of characteristic degenerative changes of the nuclei in the form of pyknosis, karyorrhexis
, and karyolysis (Figure 1(b)).
b) A segment of the glomerulus showing fibrinoid necrosis and karyorrhexis
(arrow) (H&E 400x).
Necrosis of tubular and surrounding haematopoietic cells, pycknosis and karyorrhexis
of kidney tissue were observed when coho salmon was exposed to Amitrole for 144 h (Rand and Petrocelli, 1985).
Lymphocyte necrosis is characterized by karyorrhexis
, karyolysis or chromatin clumping and in more severe cases abundant eosinophilic cellular debris may be found.
Acute necrotizing foci stippled with karyorrhexis
and fibrin exudates and small plasmacytic infiltrates were found in myocardium, peripheral nerves and perineural tissues, liver, spleen, and lungs.
Nucleolar damage of photoreceptors that occurred after exposure include an early stage of nucleolar condensation (Figure 6B), karyolysis (Figure 6C), pyknosis (Figure 6D-E), and karyorrhexis