Knoevenagel reaction [kə′nē·və‚näg·əl rē‚ak·shən]
Knoevenagel Reaction
(organic chemistry)
The condensation of aldehydes with compounds containing an activated methylene (=CH2) group.
Knoevenagel Reaction
the condensation of aldehydes or ketones with compounds containing an active methylene group in the presence of bases, resulting in the formation of ethylene derivatives. For example, a derivative of cinnamic acid (III) is obtained during the condensation of benzaldehyde (I) with the diethyl ester of malonic acid (II) in the presence of piperidine:
The Knoevenagel reaction is widely used in the laboratory for organic synthesis and in the chemical-pharmaceutical and perfume industries. The German scientist E. Knoevenagel discovered the reaction in 1896.
REFERENCE
Surrey, A. Spravochnik po organicheskim reaktsiiam. Moscow, 1962. (Translated from English.)Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content.
| ?Page tools | ||
|---|---|---|
|