kynurenic acid

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kynurenic acid

[¦kin·yə¦ren·ik ′as·əd]
(biochemistry)
C10H7O3N A product of tryptophan metabolism found in the urine of mammals.
References in periodicals archive ?
The induction of IDO and TDO leads to increased concentration of kynurenine pathway metabolites, mostly kynurenic acid and quinolinic acid.
0 mM) for 24 h Kynurenic acid (KYNA), a tryptophan metabolite known to own mitochondrial protection effect and attenuate [MPP.
As reported in the January 15, 2015 issue of Cell, the researchers found that when worms were given access to food after they d been denied it, they would overeat for a while before resuming their typical feeding pattern, a change in behavior triggered by falling levels of kynurenic acid.
When researchers decreased the levels of kynurenic acid in the brains of mice, their cognition was shown to improve markedly, according to the study.
Furthermore, we also confirmed the functional importance of altered expressions of these receptors in the recovery process in the PIT model, using kynurenic acid as an antagonist for glycine/glutamate receptors (10).
Kynurenic acid (KYNA) is the only known endogenous N-methyl-D-aspartate (NMDA) receptor antagonist found in humans.
The effect of glutamic acid (glu) and kynurenic acid (kyn) on the metabolism of the Antarctic amphipod Abyssorchomene plebs.
Benzodiazepines or glutamate antagonists such as valproic or kynurenic acid may suppress the excitotoxic effects.
The lead author's laboratory studied the effects of a broad-spectrum glutamate receptor antagonist, kynurenic acid (KYNA), on glutamate- and noise-induced trauma in guinea pigs.
However, it has been demonstrated that posttraumatic potassium increase is associated with a glutamate increase following fluid percussion induced TBI and that administration of kynurenic acid (EAA blocker) greatly reduced extracellular potassium increases and improved outcome.
7-CI-KYNA is a synthetic analogue of kynurenic acid, which is a naturally occurring neural regulatory compound and one of the most potent and selective blockers of the regulatory GlyB-site of the NMDA receptor.