Lazzaro Spallanzani

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Spallanzani, Lazzaro

(läd`dzärō späl-läntsä`nē), 1729–99, Italian naturalist. He was professor at the universities of Modena (1763–69) and Pavia (from 1769). Spallanzani studied regeneration, fertilization, and the digestive action of saliva; using heat-sterilized cultures, he performed experiments that disproved J. T. Needham's theory of spontaneous generation.

Spallanzani, Lazzaro


Born Jan. 12, 1729, in Scandiano; died Feb. 12, 1799, in Pavia. Italian naturalist.

Spallanzani graduated from the University of Bologna. He was a professor at universities in Reggio nell’Emilia (from 1755), Modena (from 1763), and Pavia (from 1769).

Spallanzani worked in various fields of natural science, but his studies in experimental biology are particularly well known. He was the first to demonstrate experimentally the impossibility of spontaneous generation of microscopic organisms (Infusoria). Using microscopy, he studied regeneration in amphibians; also, he was the first to carry out artificial fertilization in amphibians and mammals. He found that eggs do not begin to develop until they have made contact with sperm. However, as an ovist (an adherent of preformation), he assumed that seminal fluid rather than spermatozoa is the major factor in fertilization because it stimulates the growth of the organism, which apparently preexists in the egg. Spallanzani also studied blood circulation, respiration, digestion, and the sense organs.


Le opere, vols. 1–5. Milan, 1932–36.
Epistolario, vols. 1–5. Florence, 1958–64.


Prandi,D. Bibliografía delle opere di L. Spallanzani. Florence, 1951.
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The 250-bed, state-of-the-art Lazzaro Spallanzani institute in Rome started out in 1939 as a center for the prevention, diagnosis and treatment of infectious diseases.
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Author affiliation: Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
National Institute for Infectious Diseases IRCCS Lazzaro Spallanzani, Rome, Italy; and ([dagger]) "La Sapienza" University, Rome, Italy
Address for correspondence: Emanuele Nicastri, National Institute for infectious Diseases IRCCS Lazzaro Spallanzani Via Ponuense 292 00149, Rome, Italy; fax: 39-6-558-2825; email: nicastri@inmi.
Address for correspondence: Vincenzo Puro, Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive, Lazzaro Spallanzani, 00149 Rome, Italy; thx: 39-065582825; email: puro@inmi.
Istituto Superiore di Sanita, Rome, Italy; ([dagger]) National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy; and ([double dagger]) Universita di Roma Tre, Rome, Italy