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meninges
(redirected from Leptomeningeal)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.10 sec.
meninges (mĭnĭn`jēz), three membranous layers of connective tissue connective tissue, supportive tissue widely distributed in the body, characterized by large amounts of intercellular substance and relatively few cells. The intercellular material, or matrix, is produced by the cells and gives the tissue its particular character.
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 that envelop the brain and spinal cord (see nervous system nervous system, network of specialized tissue that controls actions and reactions of the body and its adjustment to the environment. Virtually all members of the animal kingdom have at least a rudimentary nervous system.
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). The outermost layer, or dura mater, is extremely tough and is fused with the membranous lining of the skull. In the brain it forms a vertical sheet that separates the cerebral hemispheres and a horizontal sheet that lies between the cerebrum and the cerebellum. The thin arachnoid membrane lies below and in close contact with the dura mater. The innermost layer, or pia mater, is in direct contact with the brain and spinal cord and contains the blood vessels that supply them. The pia mater and arachnoid membrane are separated by the subarachnoid space containing the cerebrospinal fluid, which carries nutrients, absorbs the impact of shocks, and acts as a barrier to disease organisms. Thus, the meninges provide a fluid-filled jacket for the protection of neural tissues and allow for the flexing and twisting of the vertebral column about the spinal cord.

meninges

Three fibrous membranes that surround the brain and spinal cord to protect the central nervous system. The pia mater, a very thin membrane, adheres to the surface of the brain and spinal cord. The subarachnoid space, containing cerebrospinal fluid, separates the pia mater from a second membrane, the arachnoid. Around the brain, fine filaments connect these two membranes, which are believed to be impermeable to fluid. The third membrane, the dura mater, is strong, thick, and dense. It envelops the arachnoid, covers the inside of the skull, and surrounds and supports the large venous channels carrying blood from the brain. Several septa divide it and support different parts of the brain. In the spine, the dura mater and the arachnoid mater are separated by the subdural space; the arachnoid and pia mater are separated by the subarachnoid space. The extradural space (between the dura mater and the wall of the vertebral canal) is the site of epidural anesthesia (see anesthesiology).


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Facial port-wine stains and associated leptomeningeal angiomas typify the vascular findings.
Magnetic resonance imaging of the brain showed mild leptomeningeal enhancement.
The company is currently completing the filing of a New Drug Application for its lead product, DepoCyt, an anti-cancer therapeutic for the treatment of neoplastic meningitis (also known as leptomeningeal metastases) arising from sold tumors and is continuing Phase III clinical trials for leukemia and lymphoma indications.
 
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