Letterer-Siwe disease


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Letterer-Siwe disease

[′led·ə·rər ′zē·və di‚zēz]
(medicine)
A fatal disease of infants and young children, of unknown etiology, characterized by hyperplasia of the reticuloendothelial system without lipid storage.
References in periodicals archive ?
Pauline, 32, had a rare condition called Letterer-Siwe disease which stunted her growth so she is only 4ft 10in.
The differential was given as osteomyelitis, which was considered unlikely because of the sharp margins, hemangioma, and histiocytosis, or Letterer-Siwe disease.
This disease is a spectrum of three sub-types including eosinophilic granuloma, hand-schuller-christian disease and letterer-siwe disease.