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Letterer-Siwe disease

   Also found in: Dictionary/thesaurus, Medical, Legal, Acronyms, Wikipedia, Hutchinson 0.03 sec.
Letterer-Siwe disease [′led·ə·rər ′zē·və di‚zēz]
(medicine)
A fatal disease of infants and young children, of unknown etiology, characterized by hyperplasia of the reticuloendothelial system without lipid storage.


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1) At that time, histiocytosis X was subdivided into three types: (1) eosinophilic granuloma, an isolated osteolytic lesion: (2) Hand-Schuller-Christian disease, a multifocal version of eosinophilic granuloma that is often accompanied by systemic manifestations; and (3) Letterer-Siwe disease, a systemic, rapidly progressive form of histiocytosis X.
 
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