targeted by ASN-1, one of the two antibodies in the company's lead product candidate, ASN100.
responsible for lysis of human phagocytic (immune) cells: Panton-Valentine leukocidin
ED, and gamma-hemolysins AB and CB.
aureus isolates also produce one or more additional exoproteins, such as toxic shock syndrome toxin-1 (TSST-1), staphylococcal enterotoxins (SEs), exfoliative toxins (ETs), and leukocidins.
Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients.
The prevalence of genes encoding leukocidins in Staphylococcus aureus strains resistant and sensitive to methicillin isolated from burn patients in Taleghani Hospital, Ahvaz, Iran.
The frequent recovery of staphylococcal isolates that produce leukocidal toxins from patients with deep skin soft tissue infections, particularly furunculosis, cutaneous abscesses, severe necrotizing pneumonia, and even UTIs, suggests that the Panton-Valentine leukocidin (PVL) is a virulence factor that has a major role in pathogenicity [7-14].
staphylococcus protein A (a super antigen), leukocidins, and coagulase itself.
Otto's group to be a candidate factor for increased virulence, suggesting it to be more important than Panton-Valentine leukocidin (PVL).
These include some that most clinicians may recognize, for example, staphylococcus protein A (a super antigen), leukocidins
, and coagulase itself.
Effects of Staphylococcus aureus leukocidins
on inflammatory mediator release from human granulocytes.
To the Editor: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which carries genes for Panton-Valentine leukocidin
(PVL), has become a major concern worldwide (1-3).
The CA-MRSA strains shared a type IV SCCmec cassette and the Panton-Valentine leukocidin
locus, whereas the distribution of the other toxin genes was quite specific to the strains from each continent.