An oral version of the drug marketed as a generic and by Astra Zeneca as Accolate', is a first-in-class anti- leukotriene
and treatment for asthma.
This causes competitive inhibition of leukotrienes
which subsequently blocks the inflammatory effects of leukotrienes
Polymorphisms in ALOX5 and also in 5-lipoxygenase-activating-protein (FLAP) are associated with the excessive production of leukotrienes
(Koshino et al.
have been implicated in the pathogenesis of eustachian tube dysfunction, our study did not demonstrate that the leukotriene
inhibitor montelukast had any effect in clearing middle ear fluid.
5) Options for the management of these cases are to either increase the dose of ICS or to add in another controller agent, such as a long-acting beta-agonist (LABA), a leukotriene
receptor antagonist (LTRA), or a theophylline.
It works by reducing the number of leukotrienes
in the blood which cause inflammation and constriction of the lungs and airways.
That was the first approval for a leukotriene
inhibitor, a class of drugs that blocks the effect of leukotrienes
, which are potent, naturally occurring bronchoconstrictors.
In some, the allergy can move on to a second stage where chemicals called leukotrienes
and prostaglandins are released.
Harel is studying leukotrienes
, inflammatory mediators that are not well understood in the context of dysmenorrhea.
That IgE-pollen combination bonds well with mast cells, which contain histamines and leukotrienes
We produce leukotrienes
ourselves when our lung tissues come up against various chemicals in the air we breathe.
Then, in 1979, Swedish scientists characterized the chemical structure of one of the compounds, paving the way for identifying other substances in this chemical family, now called leukotrienes