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ligase |
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ligase [′lī‚gās] (biochemistry) An enzyme that catalyzes the union of two molecules, involving the participation of a nucleoside triphosphate which is converted to a nucleoside diphosphate or monophosphate. Also known as synthetase. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| The lack of measurable effects of PM on DNA strand breaks may be due to the very rapid repair by ligases, whereas guanine oxidation is repaired relatively slowly by base excision followed by strand nicking, insertion of nucleotide(s) in the gap, and rejoining by ligases (Hoeijmakers 2001; Risom et al. These include restriction endonucleases for cleaving DNA and ligases for joining the fragments, recombinases that can execute a large variety of DNA cleavage and joining reactions. D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. |
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