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Related to Lipases: Phospholipases



enzymes of the hydrolase class that catalyze the hydrolysis of ester linkages in triglycerides, with the formation of a fatty acid and glycerol. Lipases have been discovered in animals, plants (for example, in sunflower seeds), and microorganisms.

In mammals, lipases digest (decompose) fat. They are contained predominantly in pancreatic juice, from which a pure preparation of pancreatic lipase was first isolated in 1956. They are also found in the intestinal walls and in milk. Lipoprotein lipase, which catalyzes the hydrolysis of triglycerides bonded to proteins, is found in the blood plasma. The length of the chains and the degree to which the fatty acids are unsaturated have almost no influence on the activity of a lipase. Pancreatic and lipoprotein lipases hydrolyze only emulsified fats. The hydrolysis of triglycerides catalyzed by lipases is reversible. The reverse reaction is possible by means of biosynthesis.


Lipid Metabolism. New York-London, 1970.


References in periodicals archive ?
Commercially useful lipases are usually obtained from microorganisms that produce a wide variety of extracellular lipases.
For the DeGreez additive, three different lipases with attractive reactivity profiles were evaluated with several different resin systems.
The researchers determined the lipase activity at 400 MPa for the esterification of isoamyl acetate from isoamyl alcohol and acetic acid at temperatures ranging from 40 C to 80 C.
Orlistat causes malabsorption of dietary fat through inhibiting pancreatic lipase but is not a practicable agent as it causes steatorrhoea in doses required to make a meaningful difference.
Over all, lipolysis catalyzed by the action of both gastric and pancreatic lipases on triolein was significantly reduced by 37.
Table 11: World Recent Past, Current & Future Analysis for Lipases by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-55
On the basis of source, the Lipase Market has been segmented into microbial lipases & animal lipases.
Using more than 3-4 moles alcohol per mole triglyceride added in one step favours more alcohol tolerant enzymes as in many studies lipases-catalyzed biodiesel production increases with increasing methanol-to-oil ratio of 3:1 and then decreases because of the lipase inactivation by insoluble excess short chain alcohol, which exist as droplets in the reaction mixture (Ganesan et al.
For this application, transesterification seems to have advantages over other lipase catalyzed reactions, since no further purification procedures would be needed if the hydrolysis process is closely controlled.
Amylase, lipase and other measurable digestive enzymes produced by pancreatic acini are released into the circulation instead of the digestive tract when there is pancreatic tissue injury due to pancreatic ductal obstruction or other causes of pancreatic inflammation.
PME-1 is highly conserved from yeast to human and contains a motif found in lipases, which motif has a catalytic triad-activated serine as the active site nucleophile.