anticoagulant

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anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
Coagulation testing suggests our patient developed lupus anticoagulant but she had no clinical features of APS.
Lupus anticoagulant was first defined in patients with systemic lupus erythematosus as an inhibitor of coagulation leading paradoxically to thrombosis.
Management of anticoagulation during cardiopulmonary bypass in a patient with a circulating lupus anticoagulant.
In a review by Avcin and Silverman, they reported a prevalence of anticardiolipin antibodies in 44%, anti-beta2-glycoprotein 1 in 40% and lupus anticoagulant in 22% of children with SLE diagnosis, showing an important frequency of these antibodies and the risk of thrombotic events (6).
Protein C and protein S deficiency was detected in nine and two patients, respectively, and lupus anticoagulant in one.
Coagulation-based lupus anticoagulant tests were then carried out on plasma samples of each patient and control, and the results compared with the reference aPTT value.
Those studies found that when a purified extract of the BRSV was added to human plasma in vitro certain coagulation assays looked as if a lupus anticoagulant (LA) was present.
There are two blood tests that are important in making a diagnosis, Anticardiolipin antibodies and Lupus Anticoagulant which should be available from your GP or consultant.
The lupus anticoagulant antibody prolongs coagulation.
Researchers have now identified two closely related lupus autoantibodies, anticardiolipin antibody and lupus anticoagulant (together called the antiphospholipid antibodies), that are associated with risk of miscarriage.