Lysergic Acid

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Related to Lysergic Acid: Lysergic acid amide

lysergic acid

[lə′sər·jīk ′as·əd]
(organic chemistry)
C16H16N2O2 A compound that crystallizes in the form of hexagonal plates that melt and decompose at 240°C; derived from ergot alkaloids; used as a psychotomimetic agent.

Lysergic Acid


an organic acid of complex structure (C16H16O2N2) containing an indole residue. Lysergic acid crystals have a melting point of 238°C.

Lysergic acid is found in a number of ergot-generated alkaloids (ergoalkaloids), from which it can be isolated by alkaline hydrolysis. The first complete synthesis of lysergic acid was accomplished in 1954 by R. Woodward. The characteristic biological action of lysergic acid—the contraction of the uterine muscles—is expressed more weakly with lysergic acid itself than with the ergoalkaloids. On entering the organism, lysergic acid diethylamide, known as LSD, is an antagonist of serotonin, a central nervous system regulator. LSD has a strong hallucinogenic effect and is used in the treatment of certain mental diseases.

References in periodicals archive ?
of Participating Laboratories in 2008, n = 3 survey Drug or Class of Drugs mailings Amphetamines 2844 MDMA 371 Barbiturates 2765 Benzodiazepines 2719 BE/Cocaine 2830 THC 2767 Ethanol 523 Methadone 1232 Methaqualone 110 Opiates 2781 Oxycodone 267 Phencyclidine 2325 Propoxyphene 468 Tricyclics 1121 LSD 14 Abbreviations: BE, benzoylecgonine; LSD, lysergic acid diethylamide; MDMA, methylenedioxymethamphetamine; THC, tetrahydrocannabinol.
1] Nonstandard abbreviations: MDMA, 3,4-methylenedioxymethamphetamine (Ecstasy); LSD, lysergic acid diethylamide; HHMA, 3,4-dihydroxymethamphetamine; HMMA, 4-hydroxy-3-methoxymethamphetamine; HMA, 4-hydroxy-3-methoxyamphetamine; MDA, 3,4-methylenedioxyamphetamine; HHA, 3,4-dihydroxyamphetamine; MDEA, 3,4-methylenedioxy-N-ethylamphetamine; SPE, solid-phase extraction; QC, quality control; LOD, limit of detection; LOQ, limit of quantification.
A Damien Hirst print, entitled Lysergic Acid Diethylamide, was expected to sell at between pounds 8,000 and pounds 10,000, while an Alexander Millar oil painting, Goal, was given an estimate of pounds 10,000 - pounds 12,000.
IN JANUARY the Swiss inventor of lysergic acid diethylamide, Albert Hofmann, turned 100 and was honored at a Basel symposium called "LSD: Problem Child and Wonder Drug" Hofmann first synthesized the hallucinogen in 1938, and the pharmaceutical giant Sandoz (now Novartis) began marketing the drug as a treatment for psychological problems a decade later.
The number of past-year users of lysergic acid diethylamide (LSD) declined 41% between 2002 and 2004, while past-year use of ecstasy dropped 40% over the same period.
Albert Hoffmann, a senior researcher at Switzerland's Sandoz headquarters, first synthesised lysergic acid diethylamide (LSD) from a fungus, and used it as a painkiller.
In other cases, lysergic acid (LSD) was given to individuals without their consent, and biological weapons, such as infectious agents that resulted in Venezuelan equine encephalitis and tularemia, were sprayed over parts of St.
This book purports to be primarily concerned with the history of the illegal psychedelic drug lysergic acid diethylamide (LSD).
The film is set in Berlin's spring-blooming Tiergarten; its only props are a playing card, a clothespin, a vintage German bicycle, a thermos, and last but not least, a blotter of lysergic acid diethylamide, which Graham casually drops on his tongue while reposing on a rock.
Lung cancer produces lysergic acid, which interrupts the signal sent by the brain to keep cells alive.
The drug - full name lysergic acid diethylamide - later became notorious for its illegal use in the Sixties.