MLT

(redirected from MALT1)
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MLT

(MultiLink Trunking) See 802.3ad.
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Ibrutinib plus proteasome or MALT1 inhibitors overcome resistance to BCR antagonists in CARD11 mutant-expressing B-lymphoma cells (Abstract 1742; Poster 15) Inhibitors of UPS and HSP90 Pathways and Other Targets.
VIB and CD3 (KU Leuven) have signed a license and collaboration agreement with AstraZeneca for the development of novel MALT1 inhibitors as therapeutics in inflammatory and oncological diseases.
4) The t(11;18)(q21;q21) chromosomal translocation, resulting in the production of a fusion protein composed of the apoptosis inhibitor API2 on chromosome 11q21 and the paracaspase MALT1 on chromosome 18q21, is the most common structural abnormality identified in the primary pulmonary MZL.
Similar to its systemic counterpart, diffuse large B-cell lymphoma, but unlike PCFCL, fluorescent in situ hybridization studies reveal that 80% of PCLBCL, LT cases have breakpoints in at least one loci involving IGH, MYC, BCL6, or MALT1 genes (2).
Researchers at the University of Michigan Comprehensive Cancer Centre found that once the proteins API2 and MALT1 fuse together in a subset of lymphomas, they bind to an enzyme called NIK.