monoamine oxidase inhibitor

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Related to MAO inhibitor: Ritalin, SSRI, serotonin, COMT inhibitor, MAOI inhibitor

monoamine oxidase inhibitor

[män·ō′am‚ēn ′äk·sə‚dās in′hib·əd·ər]
(pharmacology)
Any drug, such as isocarboxazid and tranylcypromine, that inhibits monoamine oxidase and thereby leads to an accumulation of the amines on which the enzyme normally acts.
References in periodicals archive ?
To summarize, resveratrol, quercetin, pterostilbene, and caffeic acid actually impaired the detection of the produced hydrogen peroxide without preventing benzylamine degradation and behaved as MAO inhibitors and SSAO inhibitors only in appearance, as schematized in Figure 7.
It is probable that one of the leading causes of protracted depressive states may be an autoimmune process, and specifically, the formation of auto-antibodies to the endogenous MAO inhibitor isatin or isatin containing tribuline.
MAO inhibitors like Parnate block the enzyme monoarnine oxidase, which breaks down serotonin and norepinephrine.
more than 150 mg) of tyramine by patients taking MAO inhibitors, including Azilect([R]), should be avoided.
At a meeting, the FDA's Psychopharmacologic Drugs Advisory Committee voted 7-4 that the available data supported the "reasonable safety" of the 20-mg formulation of a transdermal patch containing the irreversible MAO inhibitor selegiline without a recommendation to restrict aged cheeses and other tyramine-rich foods in the diet.
The approval marks another first: The lowest dose--the 20-mg patch that delivers 6 mg of selegiline over 24 hours--does not require dietary tyramine restrictions, making this the first MAO inhibitor approved for treating depression without such a restriction.
1% of all antidepressant prescriptions were for an MAO inhibitor, according to data from IMS provided by Somerset at the meeting.
Conventional MAO inhibitors interfere with the action of an isoenzyme, MAO-A, that normally prevents the absorption of tyramine, a food component that can raise blood pressure dramatically, he said.
Zinx[TM] Chlor-D and Zinx[TM] PCM are also contraindicated in patients with severe hypertension, severe coronary artery disease, patients on MAO inhibitor therapy, patients with narrow angle glaucoma and/or peptic ulcer.
The most treatment-refractory patients may respond to a tricyclic, possibly in combination with an SSRI, or to an MAO inhibitor.
Cigarette smoke inhibits MAO activity, possibly through components other than nicotine, and the selective MAO inhibitor selegiline reduced craving and smoking in a lab study.