protein kinase

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Related to MAPK: MEK, PI3K

protein kinase

[¦prō‚tēn ′kī‚nās]
(biochemistry)
An enzyme that exerts regulatory effects on growth and malignant transformation by phosphorylating proteins.
References in periodicals archive ?
The p38 MAPK pathway has been implicated in the induction of apoptosis by varying extracellular stimuli (Dolado et al.
Although we do not yet fully understand the molecular mechanisms in freshly isolated oocytes that are needed to maintain MII spindle dynamics, we know that MAPK and MPF are important.
20,31) Sequence comparisons have revealed that each p38 isoform shares ~60% identity within the p38 group but only 40% to 45% to the other 3 MAPK family members.
He et al (22) showed that both PI3K/Akt/FKHRL1 and P44/ 42 pathways provided the downstream signaling by specific inhibitors of PI3K, Akt and MAPKs (p44/42, p38, and JNK).
Conclusions: Base excision repair proteins along with regulating MAPK may be useful for repairing oxygen damage in lung cells.
5A, Saxi A treatment in both cell lines increased ERK 1/2 and p38 MAPK phosphorylation in a time-dependent manner.
MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide.
Hyperactivation of the p38 MAPK cell-signaling pathway inhibits the renewal of muscle stem cells in aged mice, perhaps because of cellular stress and inflammatory responses acquired during the aging process.
They then examined the subsequent molecular activity of both MAPK and PKA.
There are three main mechanisms of action for the ERs: a) the classical nuclear, genomic mechanism, in which ligand-bound ERs interact directly with estrogen response elements (EREs) to regulate transcription; b) the nonclassical nuclear, genomic "tethered" mechanism, in which ER interacts with other transcription factors on sites such as AP-1 or Sp1 to regulate gene expression; and c) the rapid nongenomic action mechanism, which activates signaling cascades involving p44/42 MAPK (p44/42 mitogen-activated protein kinase), sRC, and Akt (Burns et al.