nitrogen mustard

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nitrogen mustard,

any of various poisonous compounds originally developed for military use (see poison gaspoison gas,
any of various gases sometimes used in warfare or riot control because of their poisonous or corrosive nature. These gases may be roughly grouped according to the portal of entry into the body and their physiological effects.
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). Like mustard gas and lewisite, it is a vesicant (blistering agent). In the form of its crystalline hydrochloride it is used as a drug in the treatment of Hodgkin's diseaseHodgkin's disease,
a type of cancer of the lymphatic system. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly.
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, non-Hodgkin's lymphomaslymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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, and brain tumors. Nitrogen mustards cause mutations in the genetic material of cells, thereby disrupting mitosis, or cell division. Cells vary in their susceptibility to nitrogen mustards, with rapidly proliferating tumor and cancer cells most sensitive; bone marrow, which produces red blood cells, is also sensitive, and depression of red blood cell production is a frequent side effect of nitrogen mustard therapy. The nitrogen mustards also suppress the immune response (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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).

nitrogen mustard

[′nī·trə·jən ′məs·tərd]
(organic chemistry)
Any of the substituted mustard gases in which the sulfur is replaced by an amino nitrogen, such as for methyl bis(2-chlorethyl)amine, (CH2ClCH2)2NCH3; useful in cancer research.
References in periodicals archive ?
Third, the theoretical formula-based estimation of MOPP might not reveal the actual physiological position of ocular perfusion.
Another key point in the proposed method was taking advantage of the fact that the time histories of Tcore and HR were first order for constant work rate (WR), MOPP and environmental conditions.
Thus, the Tcore and HR time histories could be predicted for each individual within the range of inputs for 18 cases (3 environmental conditions x 3 MOPP levels x 2 Work rates=18 cases) using 18 different neural networks plus the model that generated the initial values.
MOPP Configurations--clo Values are for a Very Low Windspeed (<0.
Designating guidance for lowering MOPP levels in zones free of contamination.
1) TPs are used to admit uncontaminated personnel into MOPP 4 zones and to transition personnel with minimal contamination between hot and cold zones (following the decontamination of boots and gloves and the completion of cleanliness verification).
The first two attacks were out of sector, and we expected the element to initiate a MOPP analysis and then prepare to execute the CBRNWRS.
4 Protect yourself from injury by assuming correct MOPP.
It also exercises the NBC channels of communication from higher headquarters to lower, between the intelligence (G2/S2) and operations (G3/S3), and forces the unit commanders to conduct a MOPP analysis.