methotrexate

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methotrexate,

drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemialeukemia
, cancerous disorder of the blood-forming tissues (bone marrow, lymphatics, liver, spleen) characterized by excessive production of immature or mature leukocytes (white blood cells; see blood) and consequently a crowding-out of red blood cells and platelets.
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, psoriasispsoriasis
, occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the overproduction of skin cells.
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, and non-Hodgkin's lymphomalymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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. By binding to an enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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 that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acidsnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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 and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritisarthritis,
painful inflammation of a joint or joints of the body, usually producing heat and redness. There are many kinds of arthritis. In its various forms, arthritis disables more people than any other chronic disorder.
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.

methotrexate

[‚meth·ə′trek‚sāt]
(pharmacology)
References in periodicals archive ?
As far as local data is concerned, the safety of MTX + LEF has only been analyzed on a pool of 20 patients10.
The remarkable increase in MTX uptake by cells endowed by the association to LDE may have been accounted, at least in part, for the marked results in heart-grafted animals found in this study.
veterans with RA and compared the adherence and persistence of triple therapy and MTX + TNFi as a surrogate for their relative clinical effectiveness.
Data from 98 patients diagnosed with EP between January 2010 and December 2015 in Yildirim Beyazit University, who were treated by systemic MTX or surgery were reviewed retrospectively.
Hydration and alkalinization are implemented 12 h before MTX infusion using 200 ml of 5% sodium bicarbonate (NaHCO[sub]3), 10 ml of 15% potassium chloride, as well as 1 L of 5% glucose and 5% glucose and normal saline (GNS).
It can be debated whether systemic MTX is the treatment of choice.
This is the first study regarding the efficacy and safety of the MTX in LP in Pakistan.
It was designed in Phoenix, Arizona for Elio Motors by MTX Audio.
This reduces the likelihood of an osteoporotic fracture and increases the presumption that MTX plays a role in these fractures.
One year after vaccination, the patient is receiving a 10 mg weekly dosage of MTX and his PA is controlled.
The researchers compared the results of initial MTX monotherapy with the option to step up to combination therapy with immediate initial combination therapy in patients with RA and an early poor prognosis.
Metotreksat'a bagli pansitopeni acisindan risk faktorleri olan dehidratasyon, yuksek ortalama eritrosit volumu (MCV) duzeyi, hipoalbuminemi, haftalik yerine gunluk MTX alimi, renal yetmezlik, dusuk folat duzeyi, folik asit almama, ileri yas, enfeksiyon, multipl sayida ilac kullanimi gibi durumlarda MTX alan RA'li hastalarin takibinde, hematolojik toksisite gelisimi daha sik olmaktadir (3-6).