methotrexate

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methotrexate,

drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemialeukemia
, cancerous disorder of the blood-forming tissues (bone marrow, lymphatics, liver, spleen) characterized by excessive production of immature or mature leukocytes (white blood cells; see blood) and consequently a crowding-out of red blood cells and platelets.
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, psoriasispsoriasis
, occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the overproduction of skin cells.
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, and non-Hodgkin's lymphomalymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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. By binding to an enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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 that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acidsnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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 and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritisarthritis,
painful inflammation of a joint or joints of the body, usually producing heat and redness. There are many kinds of arthritis. In its various forms, arthritis disables more people than any other chronic disorder.
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.

methotrexate

[‚meth·ə′trek‚sāt]
(pharmacology)
References in periodicals archive ?
MTX Audio's expertise in developing integrated sound components for the power sports and motorcycle markets, especially its ability to design in flexibility and utilize unique packaging, were among the reasons it was selected as a supplier partner with Elio Motors.
MTX will additionally be displaying a Can-Am Maverick built by UTVUnderground.
Hastanin RA icin 5 yildir haftada 3 kez 2,5 mg/gun (7,5 mg/ hf) MTX ve nonsteroid antiinflamatuvar ilac (NSAII) aldigi ve son 1 aydir ise MTX dozunun haftada 4 gun 2,5 mg/gun (10 mg/ hafta) dozuna cikarildigi ogrenildi (kumulatif MTX dozu 3037 mg).
Briefly, the level of MDA, a major degradation product of lipid peroxidation, was significantly increased in MTX treated mice compared with the control group (p < 0.
The aim of this present study was to explore the utility of the principles of niosomal drug delivery systems to formulate a sustained release system for MTX alone and along with bioenhancers (a mixture of piperine and curcumin) by thin film hydration technique such that an increased entrapment, with increased storage stability and prolong release could be achieved.
Overall these highly technical results translated into a finding that enteral O3 given orally did not change intestinal parameters significantly in control animals, but had significant impacts on those treated with MTX, a common chemotherapy drug.
Despite this, convincing and validated randomized clinical trial (RCT) data demonstrated that the combination of TNFi plus a DMARD (usually MTX) is typically superior to either alone, and that there is no statistical difference when comparing TNFi to MTX when used in monotherapy.
4), (5) PatIents wIth RA that also have cerebral or cardiac problems use antiplatelet agents, for example acetylsalicylic acid, ticlopidine, or clopidogrel, in addition to MTX.
Investigators tailored the MTX treatment to each patient with the goal of achieving remission.
Because MTX could not be measured accurately and because of concern for ongoing MTX toxicity, a second [CPDG.