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92,93) Thus, although c-myc amplification and/or overexpression may promote pancreatic carcinogenesis, (94) upregulation of MXI1 may occur during disease progression to refine cmyc oncogenic signals and to protect cancer cells from cmyc- induced apoptosis.
6,7) The microsatellite markers analyzed were associated with tumor suppressor genes including CMM, MYCL, VHL, APC, MCC, CDKN2A, PTEN, MXI1, TP53, and NF2.