macrolide

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macrolide

[′mak·rə‚līd]
(organic chemistry)
A large ring molecule with many functional groups bonded to it.
References in periodicals archive ?
40) The authors found that a reduction of macrolide antibiotic consumption in Finland led to a reduction in streptococci macrolide resistance from 16.
pneumoniae had already received 14-membered macrolide antibiotics for three days (median) before hospitalization and high fever persisted during hospitalization even with continuing use of macrolides.
Non antimicrobial activity: Apart from its conventional antibacterial action macrolide antibiotics are known to have anti-inflammatory (6), immunomodulator acitivity (7 & 8) and antioxidant properties (9) and Erythromycin has been used clinically for its stimulatory effect on gastrointestinal motility.
Vitamin C, macrolide antibiotics, echinacea, ginseng Likely to be ineffective or harmful
Macrolide antibiotics are the first-line treatment for M.
Use of the macrolide antibiotic was associated with a significantly greater incidence of hearing decrement, although the overall rate was low and tended to reverse when the drug was stopped, Dr.
Macrolide antibiotics are composed of a large ring (14 to 16 carbons) on which several sugars are attached, some of these are amino sugars with diethylamino group.
More recently identified ototoxic agents Antiseptics/disinfectants Topical antibiotics Alcohol All aminoglycosides Chlorhexidine Chloramphenicol Polymyxin Macrolide antibiotics Azithromycin Others Clarithromycin Iron chelating agents Erythromycin Nonsteroidal anti inflammatory drugs Table 3.
The primary goal of the new program, Spigelman and others involved in the project say, is to optimize the antituberculosis activity of macrolide antibiotics through the synthesis of additional chemically modified erythromycin derivatives.
Macrolide antibiotics remain the mainstays of pertussis treatment and prophylaxis, although good evidence for their use remains surprisingly scanty, Dr.
The company is initially focusing on new chemical entities derived from existing drugs that address significant unmet medical needs: (a) new-generation macrolide antibiotics to overcome bacterial resistance; and (b) anti-inflammatory drugs for a variety of indications, including asthma, psoriasis and inflammatory bowel diseases.