Mast Cell

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Related to Mast Cell: Mast cell tumor, mast cell stabilizers, Mast cell disease

mast cell

[′mast ‚sel]
A connective-tissue cell with numerous large, basophilic, metachromatic granules in the cytoplasm.

Mast Cell


(also called mastocyte or labrocyte), a reticular connective tissue cell in animals and man. The number of mast cells depends on the species and on the functional state of the connective tissue. The mast cell contains metachromatic cytoplasmic granules; the size and number of granules depend on the species and on the maturity and functional state of the cell. Mast cells contain a number of physiologically active substances, notably heparin, histamine, and serotonin. Consequently, it is believed that the mast cell plays a role in anaphylaxis, inflammation, and blood clotting. Mast cells rarely divide by mitosis. The principles of their origin and reproduction remain obscure.

References in periodicals archive ?
In addition to launching Mast Cell Connect, Blueprint Medicines today launched a disease awareness website called " Together with Systemic Mastocytosis.
Type 3 variant includes patients with coronary thrombosis (including stent thrombosis), in whom aspirated thrombus specimens stained with haematoxylin-eosin and Giemsa demonstrate the presence of eosinophils and mast cells, respectively.
This is based on its mode of action because the drug must already be present to prevent mast cell degranulation.
Negative (no stimulation with the mast cell secretagogues) and positive (stimulation with the mast cell secretagogues) controls were included in all the experiments.
Our patient did achieve a complete remission of AML with this regimen, albeit there was a persistent mast cell infiltrate.
Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cell.
The early phase is generated by mast cell and basophil mediators that also initiate the later phase events.
I also started her on low-dose progesterone because her measured estrogen was elevated and her progesterone was low, resulting in mast cell and basophil degranulation with corresponding release of histamines and leukotrienes, which in turn results in allergic reactions.
Owing to the reticulin fibrosis frequently associated with the mast cell aggregates, bone marrow aspirate smears may not be helpful in identifying the atypical cytologic features.
Electron micrographs of biopsies of fentanyl-induced wheals revealed no mast cell degranulation and the authors stated that opioid-induced vascular responses are mediated by both histamine release from skin mast cells and direct effects on the vasculature (69) (see below for further discussion).
Clinical outcome of dogs with grade-II mast cell tumors treated with surgery alone: 55 cases (1996-1999).