We are proud to support the creation of Mast Cell
Connect, the first-ever open-model registry to capture the perspective of patients living with mastocytosis," said Jeffrey Albers, Chief Executive Officer of Blueprint Medicines.
Infiltrates of activated mast cells
at the site of coronary atheromatous erosion or rupture in myocardial infarction.
Pretreatment is necessary for inhibition of mast cell
The effect of varying concentrations of hydroxytyrosol and oleuropein on the secretagogue-induced [beta]-hexosaminidase release from mast cells
is shown in Fig.
The pathogenesis of SM associated with AHNMD is unknown, and the non-mast cell
lineage component might or might not show evidence of the same c-kit mutation seen in the neoplastic mast cells
Accumulation of low density lipoproteins in stimulated rat serosal mast cells
during recovery from degranulation.
IgE binds to local mast cells
, triggering degranulation and release of histamine when their antigen is encountered.
The researchers continued to investigate the role of mast cells
in attacking dengue virus in humans, and identified a biomarker - a mast cell
-derived product - that appeared to predict the illness' most severe cases in human patients.
are required for experimental oral allergen-induced diarrhea.
can cause allergic symptoms by stimulating estrogen receptors on mast cells
and basophils, and by potentiating the effect of IgE antibodies on mast cells
In hematoxylin-eosin-stained tissue sections, normal and reactive mast cells
have round to oval nuclei with clumped chromatin, a low nuclear to cytoplasmic ratio, absent or indistinct nucleoli, and abundant eosinophilic cytoplasm.
The target of oral therapy is glycosaminoglycan (GAG) layer dysfunction, mast cell
abnormalities and neurogenic inflammation.