Mast Cell

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mast cell

[′mast ‚sel]
A connective-tissue cell with numerous large, basophilic, metachromatic granules in the cytoplasm.

Mast Cell


(also called mastocyte or labrocyte), a reticular connective tissue cell in animals and man. The number of mast cells depends on the species and on the functional state of the connective tissue. The mast cell contains metachromatic cytoplasmic granules; the size and number of granules depend on the species and on the maturity and functional state of the cell. Mast cells contain a number of physiologically active substances, notably heparin, histamine, and serotonin. Consequently, it is believed that the mast cell plays a role in anaphylaxis, inflammation, and blood clotting. Mast cells rarely divide by mitosis. The principles of their origin and reproduction remain obscure.

References in periodicals archive ?
We are proud to support the creation of Mast Cell Connect, the first-ever open-model registry to capture the perspective of patients living with mastocytosis," said Jeffrey Albers, Chief Executive Officer of Blueprint Medicines.
Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction.
Pretreatment is necessary for inhibition of mast cell degranulation.
The effect of varying concentrations of hydroxytyrosol and oleuropein on the secretagogue-induced [beta]-hexosaminidase release from mast cells is shown in Fig.
The pathogenesis of SM associated with AHNMD is unknown, and the non-mast cell lineage component might or might not show evidence of the same c-kit mutation seen in the neoplastic mast cells.
Accumulation of low density lipoproteins in stimulated rat serosal mast cells during recovery from degranulation.
IgE binds to local mast cells, triggering degranulation and release of histamine when their antigen is encountered.
The researchers continued to investigate the role of mast cells in attacking dengue virus in humans, and identified a biomarker - a mast cell-derived product - that appeared to predict the illness' most severe cases in human patients.
can cause allergic symptoms by stimulating estrogen receptors on mast cells and basophils, and by potentiating the effect of IgE antibodies on mast cells and basophils.
In hematoxylin-eosin-stained tissue sections, normal and reactive mast cells have round to oval nuclei with clumped chromatin, a low nuclear to cytoplasmic ratio, absent or indistinct nucleoli, and abundant eosinophilic cytoplasm.
The target of oral therapy is glycosaminoglycan (GAG) layer dysfunction, mast cell abnormalities and neurogenic inflammation.