Mast Cell

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mast cell

[′mast ‚sel]
A connective-tissue cell with numerous large, basophilic, metachromatic granules in the cytoplasm.

Mast Cell


(also called mastocyte or labrocyte), a reticular connective tissue cell in animals and man. The number of mast cells depends on the species and on the functional state of the connective tissue. The mast cell contains metachromatic cytoplasmic granules; the size and number of granules depend on the species and on the maturity and functional state of the cell. Mast cells contain a number of physiologically active substances, notably heparin, histamine, and serotonin. Consequently, it is believed that the mast cell plays a role in anaphylaxis, inflammation, and blood clotting. Mast cells rarely divide by mitosis. The principles of their origin and reproduction remain obscure.

References in periodicals archive ?
In experimental studies, platelet aggregation, mastocyte degranulation and histamine secretion have been shown to occur after trigeminal ganglion stimulation (2).
The complex formed is recognized by mastocytes, eosinophils and neutrophils, which release the content of their granules (histamine, leukotrienes, prostaglandins and other mediators).
contortus have reported cellular infiltrations in the mucosa and regional lymph nodes, increases in T CD4+, T CD8+, T gamma delta ([gamma][delta]) and B lymphocytes, eosinophils and mastocytes [5, 11, 17, 75].