Acute venous occlusion enhances matrix metalloprotease
activity: implications on endothelial dysfunction.
Patients who improved the most on doxycycline also had the lowest activity of serine protease and matrix metalloprotease
(MMP) in their skin, reported Anna Di Nardo, MD, PhD, of the University of California San Diego in La Jolla.
Valle-Garay, "The effect of gender and genetic polymorphisms on matrix metalloprotease
(MMP) and tissue inhibitor (TIMP) plasma levels in different infectious and noninfectious conditions," Clinical and Experimental Immunology, vol.
Membrane type 1 matrix metalloprotease
cleaves laminin-10 and promotes prostate cancer cell migration.
(MMP) is an endopeptidase expressed in human urine whenever cancer is present.
regulation of neuropathic pain.
Other "targeted therapies" such as matrix metalloprotease
inhibitors, inhibitors of angiogenesis, anti-EGFR antibodies or farnesyltransferasein-hibitors failed in large phase III trials.
8:02 Matrix Metalloprotease
Activity Is Increased in Obese Dog Kidneys
AG3340, a matrix metalloprotease
inhibitor demonstrating potent anti-angiogenic and anti-metastatic properties is in Phase III clinical trials in combination with the anticancer drugs paclitaxcl/carboplatin for the proposed treatment of non-small cell lung cancer, and with mitoxantrone/prednisone for the proposed treatment of hormone-refractory prostate cancer.
Mechanical stress induces matrix metalloprotease
expression in the skin.
Of these, tyrosinase, superoxide dismutase, calalase, matrix metalloprotease
, and glutathione peroxidase are most important from skin anti-aging point of view.
New matrix metalloprotease
inhibitors are available from Bioderm Research.