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matrix metalloproteinase
(redirected from Matrix metalloprotease)

   Also found in: Medical, Wikipedia 0.02 sec.
matrix metalloproteinase [¦mā·triks mə‚tal·ō′prō·tē·ə‚nās]
(biochemistry)
Any member of a family of at least 19 structurally related zinc-dependent neutral endopeptidases collectively capable of degrading essentially all components of extracellular matrix.


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AG3340, a matrix metalloprotease inhibitor demonstrating potent anti-angiogenic and anti-metastatic properties is in Phase III clinical trials in combination with the anticancer drugs paclitaxcl/carboplatin for the proposed treatment of non-small cell lung cancer, and with mitoxantrone/prednisone for the proposed treatment of hormone-refractory prostate cancer.
and Aventis have entered into an agreement to advance the identification, discovery and validation of highly selective, orally available matrix metalloprotease (
8:02 MATRIX METALLOPROTEASE ACTIVITY IS INCREASED IN OBESE DOG KIDNEYS
 
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