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matrix metalloproteinase

   Also found in: Medical, Acronyms, Wikipedia 0.01 sec.
matrix metalloproteinase [¦mā·triks mə‚tal·ō′prō·tē·ə‚nās]
(biochemistry)
Any member of a family of at least 19 structurally related zinc-dependent neutral endopeptidases collectively capable of degrading essentially all components of extracellular matrix.


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The expression of matrix metalloproteinases 1, 2, and 9 was not significantly changed, but an increased level of tissue inhibitor of matrix metalloproteinase 1 mRNA was observed without modification of tissue inhibitor of matrix metalloproteinase 2 mRNA.
15-17) Matrix metalloproteinase 3 is considered to play essential roles in the degradation of both aggrecan and collagen fibrils in the cartilage, the latter of which may be digested through the degradation of perifibrillar extracellular matrix components such as type IX collagen (6,7) and the activation of proMMP-1, (8) proMMP-9, (19) and proMMP-13.
It comprises the use of an inhibitor of a UVB-induced matrix metalloproteinase (MMP) to inhibit the production or activity of UVB-inducible MMPs.
 
 
 
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