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matrix metalloproteinase |
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matrix metalloproteinase [¦mā·triks mə‚tal·ō′prō·tē·ə‚nās] (biochemistry) Any member of a family of at least 19 structurally related zinc-dependent neutral endopeptidases collectively capable of degrading essentially all components of extracellular matrix. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Both macrophage dysfunction and increased activity of matrix metalloproteinase (MMP) have been reported. British Biotech, Oxford, England, has reported the results of Study 131, a Phase III clinical trial of the oral matrix metalloproteinase inhibitor, marimastat. Matrix metalloproteinase activity is required for the inflammatory cell infiltration that occurs following spinal cord injury and most likely contributes to early barrier disruption. |
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