nitrogen mustard

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nitrogen mustard,

any of various poisonous compounds originally developed for military use (see poison gaspoison gas,
any of various gases sometimes used in warfare or riot control because of their poisonous or corrosive nature. These gases may be roughly grouped according to the portal of entry into the body and their physiological effects.
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). Like mustard gas and lewisite, it is a vesicant (blistering agent). In the form of its crystalline hydrochloride it is used as a drug in the treatment of Hodgkin's diseaseHodgkin's disease,
a type of cancer of the lymphatic system. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly.
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, non-Hodgkin's lymphomaslymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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, and brain tumors. Nitrogen mustards cause mutations in the genetic material of cells, thereby disrupting mitosis, or cell division. Cells vary in their susceptibility to nitrogen mustards, with rapidly proliferating tumor and cancer cells most sensitive; bone marrow, which produces red blood cells, is also sensitive, and depression of red blood cell production is a frequent side effect of nitrogen mustard therapy. The nitrogen mustards also suppress the immune response (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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).

nitrogen mustard

[′nī·trə·jən ′məs·tərd]
(organic chemistry)
Any of the substituted mustard gases in which the sulfur is replaced by an amino nitrogen, such as for methyl bis(2-chlorethyl)amine, (CH2ClCH2)2NCH3; useful in cancer research.
References in periodicals archive ?
If mechlorethamine accidently seeps out of the vein, it may damage some tissues and cause scarring.
Mechlorethamine is a chemotherapeutic agent that has previously been approved for intravenous treatment of the most common type of CTCL, namely mycosis fungoides.
Flare: a localized, self-limiting hypersensitivity response, usually to anthracycline or mechlorethamine
ProMACE-MOPP-prednisone + methotrexate + adriamycin (doxorubicin) + cyclophosphamide cytoxan) + etoposide (VP-16) + mechlorethamine + oncovin (vincristine) + procarbazine + prednisone.
The pivotal trial was a randomized, observer-blinded clinical study designed to determine if mechlorethamine gel was non-inferior to a pharmacy-compounded ointment in patients with MF.
4 October 2011 - US Yaupon Therapeutics Inc said on Tuesday that the New Drug Application (NDA) for its propriety gel formulation of mechlorethamine hydrochloride has been accepted for filing by the US Food and Drug Administration (FDA).
We believe that our proprietary mechlorethamine gel will be an important new treatment option and this latest round of financing provides Ceptaris additional capital for ongoing activities," said Stephen Tullman, President and CEO at Ceptaris.
The New Drug Application (NDA) for Ceptaris' drug candidate, mechlorethamine gel, is currently undergoing review by the U.
a privately held specialty pharmaceutical company, announced today that the European Medicines Agency (EMA) has granted Orphan Drug Designation to Ceptaris' investigational drug, chlormethine gel (also known as mechlorethamine gel in the US), for the treatment of Cutaneous T-Cell Lymphoma (CTCL).
Ceptaris Therapeutics' lead drug candidate, mechlorethamine gel is currently undergoing review by the U.
Food and Drug Administration (FDA) has accepted for filing the New Drug Application (NDA) for its propriety gel formulation of mechlorethamine hydrochloride (mechlorethamine).