In the case presented, the myeloblasts were positive for CD34 (Image 3B), megakaryocytes
were identified by factor VIII related antigen and CD71 highlighted erythroid precursors (not shown).
may also bind with IgG in the presence of quinine, resulting in apoptosis, a decrease in cell viability and an increase in cell death of the precursor cells (9).
comparison of oligonucleotide-microarray and serial analysis of gene expression (SAGE) in transcript profiling analysis of megakaryocytes
derived from CD34A+ cells.
Myeloid recovery was defined as an absolute neutrophil count of more than 500/[micro]L, and erythroid and megakaryocyte
lineage reconstitution were defined as reticulocyte counts of more than 3 x [10.
To the best of our knowledge this is a novel finding, which may lead to further insight in how megakaryocyte
maturation and platelet production change with age.
Pluripotential stem cell Myeloid Progenitors Myeloblast Monoblasts Marrow pool Mitotic Promelocytes Promonocytes precursors Myelocytes Post-mitotic Metamyelocytes bands Blood and Neutrophils, Monocytes tissue eosinophils and function basophils Innate Macrophage immunologic function Progenitors Megakaryocyte
Erythroid Lymphoid Marrow pool Mitotic Maturing Normoblasts Pre-B precursors megakaryocytes
Post-mitotic Reticulocytes B lymphoblast Blood and Platelets Erythrocytes B tissue lymphocytes function and plasma cells Haemostasis Oxygen Adaptive transport immunologic function Progenitors Marrow pool Mitotic Pro-T precursors Post-mitotic Lymphoblast Blood and T-lymphocytes tissue and NK cells function Fig.
In the past decade it has been thought that platelets are formed by megakaryocytes
through a process similar to cell death, said Drs Emma Josefsson.
PMF is characterized by ineffective erythropoiesis and abnormal megakaryocyte
(Figure 4) are commonly seen and are identified by the presence of large multilobulated nuclei.
TPO is one of the major hematopoietic regulators that function in megakaryocytopoiesis, or the proliferation and differentiation of megakaryocytes
resulting in platelet production.
Evaluation of bone marrow aspiration revealed normal cellular distribution and maturation, but an increased number of megakaryocytes
These cells give rise exclusively to megakaryocytes
and platelets, as evidenced by their growth and differentiation in vitro and in vivo.