Also found in: Dictionary, Medical, Wikipedia.
Related to Melioidosis: Burkholderia pseudomallei


(veterinary medicine)
An endemic bacterial disease, primarily of rodents but occasionally communicable to humans, caused by Pseudomonas pseudomallei and characterized by infectious granulomas.



(pneumoenteritis, pseudoglanders), an acute infectious zoonotic disease.

The causative agent of melioidosis is the microorganism Malleomyces pseudomallei, which is similar to the glanders bacillus in antigenic and morphological properties and is pathogenic for rats, guinea pigs, rabbits, mice, dogs, and sheep. Rats, the main reservoir of infection, excrete the causative agent with their urine and feces. Under natural conditions, melioidosis is transmitted from animal to animal by the ingestion of food infected with the discharges of the diseased rats.

Melioidosis is found in Southeast Asia, Australia, and Madagascar. Cases have occurred in the USA, Indonesia, and the Philippine Islands. No verifiable cases of melioidosis in man have been recorded on the territory of the USSR. Infection from humans affected with the disease has not been observed. Melioidosis is transmitted from sick animals through food or water. The condition is manifested by diverse symptoms resembling those of glanders, plague, cholera, and certain other diseases. Preventive measures include exterminating rats and protecting food products and drinking water from contamination with the excretions of diseased animals. Hospitalization of the patient is imperative. The focus of the disease should be disinfected.


Melioidosis in animals may be acute, subacute, or chronic. In sheep and goats symptoms of the disease include cough, polyarthritis, and affection of the prescapular lymph nodes. In dogs, cats, and rodents, symptoms include diarrhea, purulent conjunctivitis, vaginitis, and rhinitis, with the formation of irregularly shaped ulcers and abscessed lymph nodes. Cachexia develops. Diagnosis of the condition is made on the basis of the clinical symptoms, autopsy, and bacteriological examination. A specific course of treatment has not yet been developed, and attempts to cure the diseased animals have proved ineffective.

Melioidosis can be prevented in animals by exterminating rodents, the principal natural reservoir of the infection. When an animal is suspected of having contracted the disease, it should be isolated and subjected to bacteriological examination. If the condition is confirmed, the animal should be killed and cremated, with care taken to avoid infection.


Epizootologiia. Edited by R. F. Sosov. Moscow, 1969.
Rudnev, G. P. Antropozoonozy. Moscow, 1970.
References in periodicals archive ?
The unusual finding of extensive mediastinal disease raised the possibility that the patient had inhalational melioidosis.
However, serology may be helpful to rule out melioidosis in suspected cases2.
Murray Valley encephalitis, Ross River fever, scrub typhus and dengue could increase their distribution * possibly of malaria in the Northern Territory, especially in the Kakadu region, and yellow fever in north Queensland * dengue fever may occur as far south as Tasmania by the year 2030 * diarrhoeal illnesses, amoebic meningoencephalitis, melioidosis and poisoning from cynobacterial (blue-green algae) blooms liable to increase
To the Editor: Melioidosis is an infection with clinical manifestations ranging from skin abscess to overwhelming sepsis and death.
The natural occurring bacteria called Melioidosis has caught the attention of the US Government because of its potential to be used as biological weapon.
2) Fortunately, all workers were provided antibiotic prophylaxis within 48 hours of exposure with no patients developing melioidosis.
The picture was quite different from the panlobular microvesicular steatosis of Reye's syndrome (22) or that of viral hepatitis or infectious diseases involving the liver, such as melioidosis, typhoid fever or malaria.
The Soviet Union had focused on smallpox, plague, Q-fever, Marburg hemorrhagic fever, melioidosis, and typhus (4).
Analysis of the major threat areas in the biodefense market including - anthrax, plague, tularemia, small pox viral hemorrhagic fevers, botulism, ricin, staphylococcal enterotoxins, brucella, glanders, melioidosis and Q fever.
During 19892009, a total of 540 cases of melioidosis were documented in a prospective melioidosis study based at Royal Darwin Hospital (latitude 12.
Salmonella species, Escherichia coli 0157: H7, Shigella) * Glanders (Burkholderia mallei) * Melioidosis (Burkholderia pseudomallei) * Psittacosis (Chlamydia psittaci) * Q fever (Coxiella burnetii) * Ricin toxin from Ricinus communis (castor beans) * Staphylococcal enterotoxin B * Typhus fever (Rickettsia prowazekii) * Viral encephalitis (alphaviruses [e.