sclerosis

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sclerosis

1. Pathol a hardening or thickening of organs, tissues, or vessels from chronic inflammation, abnormal growth of fibrous tissue, or degeneration of the myelin sheath of nerve fibres, or (esp on the inner walls of arteries) deposition of fatty plaques
2. the hardening of a plant cell wall or tissue by the deposition of lignin

Sclerosis

 

the hardening of an organ or tissue in humans and animals caused by connective-tissue overgrowth. Functionally valuable elements of the parenchyma of a sclerosed organ are destroyed and replaced by mature and sometimes coarse-fibered connective tissue, which often contains deposits of amyloid, hyalin, and lime. New connective tissue is usually formed by the reproduction of fibroblasts (connective-tissue cells) and by the intensified formation of collagen molecules by the fibroblasts.

In cases of sclerosis, parenchymal elements may be destroyed by inflammatory processes that are usually chronic in nature, including tuberculosis, rheumatic fever, and syphilis, and by circulatory disturbances, including passive congestion. Parenchymal elements may also be destroyed by involutional changes, for example, the postpartum sclerosis of the corpus lutea, and by changes associated with age and by metabolic disturbances. Sclerosis may be focal or diffuse. The proliferated connective tissue may become corrugated, resulting in the deformation of the organ, or cirrhosis. During cirrhosis, the hardening and reduction of an organ are accompanied by surface changes, including alternating outpouchings and invaginations, such as in a granular kidney or nodular liver.

sclerosis

[sklə′rō·səs]
(pathology)
Hardening of a tissue, especially by proliferation of fibrous connective tissue.
References in periodicals archive ?
This was followed by vascular diseases (infarct/thrombosis), congenital malformations, tumours, encephalitis, phakomatoses, mesial temporal sclerosis, leucodystrophy and cavernous angioma.
In medically refractory epilepsy patients, careful analysis for signs of mesial temporal sclerosis is undertaken, as it is the most common pathology found in these patients.
Using this technique, mesial temporal sclerosis is diagnosed when there is hippocampal volume loss and increased T2-weighted signal with loss of normal internal hippocampal architecture.
Acquired causes (Total 32cases) includes Mesial temporal sclerosis (17 cases), hypoxic ischemic encephalopathy (2 cases), neurocysticercosis (1 case), cerebral infarct with gliosis (8 cases), metastasis (1 case) & meningioma (3cases).
The predictive value of intraoperative electrocorticography in resections for limbic epilepsy associated with mesial temporal sclerosis.
One of them, temporal lobe epilepsy (TLE) due to mesial temporal sclerosis, is the most common type of human epilepsy.
In cases of mesial temporal sclerosis, the hippocampus-to-background contrast is significantly better for fast FLAIR than for spin-echo imaging.
Out of the 16 patients, nine had left-sided mesial temporal sclerosis.