BioGaia AB (STO:BIOGB), a Swedish healthcare company that develops, markets and sells probiotic products with documented health benefits, announced on Wednesday that two recent new meta-analyses
have been published investigating the effects of L.
Conventional pairwise meta-analyses
for all outcomes and comparisons were performed using a random-effects model by STATA (version 12.
Gage, Cook, and Reichow investigated the influence of publication bias on meta-analyses
conducted in special education.
This article begins by reviewing the logic for greater uptake of systematic literature reviews and meta-analyses
in policy analysis.
However, the potential strengths of meta-analyses
significantly rely on their reporting quality.
Methods: Electronic database PubMed (between 1966 and June 2015) was searched for systematic reviews and meta-analyses
using following search terms: ("garlic" OR "allium sativum" OR "allicin" OR "organosulfur") AND ("cardiovascular" OR "coronary" OR "cholesterol" OR "triglyceride" OR "atherosclerosis" OR "blood pressure" OR "hypertension" OR "blood glucose") AND ("systematic review" OR "meta- analysis"), with no restriction to calendar data and language.
As with all publications, the usefulness of meta-analyses
depends largely on the manner in which they are conducted.
allow for the pooling of data when studies are sufficiently similar in design and endpoint, they enable interpretation and observation of effect across a greater population.
Although it is true that meta-analyses
allow researchers to improve statistical power by increasing the probability of finding the effect of an intervention by combining the individual results of several studies--especially when the studies lack an appropriate sample size, it is also true that meta-analyses
offer us the opportunity to clarify why results may differ in the direction of effect depending on the characteristics of the studies.
To conduct this assessment, random-effects meta-analyses
were used to generate weighted group mean differences and 95% confidence intervals (CIs) between the EPA+DHA group and the placebo group.
The six meta-analyses
incorporated a total of 26 randomized trials of beta-blockers versus placebo.
The results of these analyses, in addition, demonstrate the extent to which researchers may be confident in previously conducted meta-analyses
that did not have the tools to adjust the effects and variance in such designs.