meta-analysis

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Related to Metaanalysis: Systematic review

meta-analysis

a method by which the results of a number of quantitative studies can be analysed together to produce an overall impression from a field of research. This method lays emphasis on EFFECT SIZE as well as providing a SIGNIFICANCE TEST for the results. It has advantages over a conventional review in that it forces the analyst to evaluate the method and the results of a study more critically and that it provides an objective method for synthesizing the results from such studies. There are two basic approaches to meta-analysis. The first and most common approach involves combining the results from the studies in order to produce a single effect size, inferential statistic and probability. The second approach involves comparing studies which differ over some aspect of their method to see if the results of studies which utilized one design or measure differ from the results of studies employing a different design or method. By combining the results of a number of studies, meta-analysis can circumvent the problems of low STATISTICAL POWER which may characterize the individual studies. (See Cooper; 1998; Cooper and Hedges, 1994; Rosenthal, 1991)
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Results from this metaanalysis support the hypothesis that consumption of vegetables and fruits could reduce the risk of stroke.
The metaanalysis of the 107 MTHFR studies (86 previous publications reporting on 88 studies (1) and the 19 new ones) that compared IHD risk in TT and CC individuals (76 792 individuals with IHD and 109 818 unaffected controls) yielded an odds ratio of1.
Although a metaanalysis of only two studies may seem inadequate, the authors wrote: "When definitive and large trials have not been performed to evaluate the impact of expedited cataract surgery on the incidence of falls, a meta-analysis of all available trials could help resolve some important issues, reducing the need for large, costly new trials.
The metaanalysis included studies that used a range of interventions, from individual cognitive-behavioral therapy, to family format, to group therapy (psychoeducation).
We conducted a metaanalysis of all eight case-control studies published between 1994 and 2005 of prenatal multivitamin supplementation and pediatric cancer rates, comparing the rates of cancer in their children with matched controls whose mothers did not use supplements.
At the upper limb, the metaanalysis showed a difference of 6.
Metaanalysis of single hospital studies is no substitute for good multicenter studies, but it could be used to provide some evidence of reproducibility and thus to prioritize targets for definitive trials.
The present study is somewhast different from traditional forms of metaanalysis [1,13] in not comparing results addressing a single question.
The results of the metaanalysis showed that the ThinPrep Pap Test was "significantly better than the conventional smear" for the diagnosis of low-grade (LSIL) and high-grade squamous intraepithelial lesions (HSIL).
Some of the potential challenges and pitfalls associated with metaanalysis are examined, and their consequences are considered.
His metaanalysis of three randomized controlled trials totaling 417 obese osteoarthritis (OA) patients also concluded that the intensity of weight loss required to achieve this benefit corresponded to a loss rate of at least 1% of baseline body weight per month, said Mr.
Lisbon -- Prenatal treatment with aspirin cut the incidence of preedampsia by 10% in a metaanalysis of results from 26 controlled studies that involved more than 30,000 women.