Hepatocyte transplantation is being evaluated as an alternative to OLT in management of hepatic metabolic conditions for long-term, albeit partial, correction of the underlying metabolic defect
Brothers of women with polcystic ovary syndrome are characterized by impaired glucose tolerance, reduced insulin sensitivity and related metabolic defects
To date, we have been unable to find the underlying metabolic defect
in this patient.
Similarities between patients with severe SMA Type 1 and those with primary metabolic defects
of mitochondrial [beta]-oxidation include:
1 In spite of detailed characterization of the hepatic contribution to diabetes, few molecules target this metabolic defect
In studies spanning mice and humans, the team discovered a pathway to disease that is activated in pancreatic beta cells, and then leads to metabolic defects
in other organs and tissues, including the liver, muscle and adipose (fat).
Drawn from those presented at a forum held October 2005 in Avallon, France, the 21 papers include such topics as folliculogenesis in polycystic ovaries, appropriate imagery, polycystic ovaries as distinct from PCOS, genetic analyses, fetal origins of PCOS, pubertal precursors, variations in expression of the PCOS phenotype, acquired PCOS and its possible causes, early recognition and prevention, the role of insulin, obesity in PCOS, therapies for metabolic defects
in PCOS, hyperabdrogenism, ovulation induction, pregnancy and the impact of diagnostic criteria.
The knowledge of this diagnosis, along with other fatty-acid metabolic defects
, may be very important to the families of affected infants because of the genetic nature of these abnormalities", Bennett said.
AntiCancer is also developing new cancer drugs based on genetic engineering that target cancer-specific metabolic defects
5 -Odczynniki for the Laboratory of Metabolic Defects
along with the lease reader