The partnership will work together to leverage Petra's pipeline of unique enzyme targets and Schrodinger's computational drug discovery platform in the design of novel small molecules for the treatment of cancer and metabolic diseases
AstraZenecas participation in the consortium complements an existing agreement between the company and the University of Michigan in which targets from AstraZenecas cardiovascular and metabolic disease
portfolio are validated for their potential in treating CKD.
The study cannot determine whether lack of sleep causes cardio metabolic disease
or if obesity itself causes sleep disturbances, they said.
He says metabolic diseases
can be present at any age but newborn babies are most vulnerable.
When the researchers infused the mutant mice with osteocalcin, the symptoms of metabolic disease
Biovitrum AB, Sweden, and Swiss-based Santhera Pharmaceuticals AG have signed a license and collaboration agreement that grants Biovitrum the exclusive worldwide rights to Santhera's DPP-IV inhibitor program to select and develop compounds and sell future drugs for a range of metabolic diseases
, including type 2 diabetes, obesity and metabolic syndrome.
Peptimmune has one product in clinical trials for the treatment of pemphigus vulgaris, and a pipeline of late stage preclinical products for the treatment of autoimmune and metabolic diseases
including, multiple sclerosis, rheumatoid arthritis and obesity.
We thought we were working on a metabolic disease
," she says, so the team paid special attention to enzymes that affect energy use and storage.
Certain cases of SIDS and sudden unexplained death beyond infancy might be attributable to complications of unrecognized metabolic diseases
A Clinical Guide to Inherited Metabolic Diseases
, 2nd edition.
Collectively, these findings demonstrate the compelling therapeutic potential of small molecule TRPV4 inhibition in obesity, type 2 diabetes and other metabolic diseases
Contact: Direct questions about scientific and research issues to Salvatore Sechi, Division of Diabetes, Endocrinology, and Metabolic Diseases
, NIDDK, 6707 Democracy Blvd, Rm 611, Bethesda, MD 20892-5460 USA, 301-594-8814, fax: 301-480-2688, e-mail: ss24q@nih.