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a class of compound proteins, complexes of proteins with metal ions.

As a rule, the bond between the protein and the metal (for example, iron, copper, zinc, magnesium, manganese, vanadium, molybdenum) is weak; nonetheless, removal of the metal (for example, with inorganic acids) destroys the structure and functional properties of the complex. Metalloproteins are widely distributed in nature and perform important biological functions, such as oxygen transport in invertebrates (hemerythrin, hemocyanin), iron storage and transport (ferritin, transferritin), and copper storage and transport (ceruloplasmin). The group includes numerous enzymes (for example, certain peptidases, tyrosinase, and aspartic acid oxidase).


Haurowitz, F. Khimiia i funktsiia belkov. Moscow, 1965. (Translated from English.)
Severin, S. E., P. P. Filippov, and G. A. Kochetov. “Metalloenzimy.” Uspekhi sovremennoi biologii, 1970, vol. 69, issue 2.
Vallee, B. L., and W. E. C. Wacker. “Metalloproteins.” In The Proteins, vol. 5. Edited by H. Neurath. New York-London, 1970.
References in periodicals archive ?
Insights into the possible role of major proteins in gel formation were obtained, and a new role for members of an important group of metalloproteins was revealed.
iNOS can modulate the expression of matrix metalloproteins (MMP) [36].
Electrochemical analysis of metalloproteins, X-ray crystallography, and molecular biology approaches are also covered.
A spectropho- tometric method for the determination of zinc, cop- per, and cobalt ions in metalloproteins.
He was intrigued because of the high incidence of Lyme disease on Cape Cod, where WHOI is located, and because he had developed new techniques to explore metalloproteins in marine life.
Smaller amounts are available for biosynthesis of metalloproteins or enzymes, as well as delivery to the crypts in the bowel, where intracellular concentrations moderate absorption.
Metallothionein-like metalloproteins in the Baltic clam Macoma baltica: seasonal variations and induction upon metal exposure.
Bertini I, Sigel A, Sigel H, (2001) Handbook on Metalloproteins.
In various infections, cysteine-containing proteins, metalloproteins, calcium transport systems, (34) as well as essential enzymes of energy metabolism (35) have been identified as important intracellular targets for the toxic actions of peroxynitrite.
This text for students with a background in the life sciences or related fields serves as an introduction to biomolecular EPR spectroscopy, its basic principles, theory, and applications, including low-spin and high-spin metalloproteins, spin traps and labels, interaction between active sites, and redox systems.
SOD previously known as erythrocuprein (human) or hemocuprein (bovine), exists as a family of metalloproteins and is widely distributed in mammalian tissues (8,9).

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