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Related to Metastase: metastasis, Metastasised


1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
2 Bone Metastases Therapeutics Market Forecast (2010-2017) - Global 18
0 criteria, bone metastases were not accepted as target lesions because they are non-measurable.
Metastatic sites, diagnostic modalities and course of disease Patient no Site of bone metastases Diagnostic modalities 1 L&S spine X-ray, CT, IS 2 Pelvis BS, IS 3 Skull, ribs, pelvis BS, X-ray, IS 4 Pelvis BS, X-ray, IS 5 Skull MRI, IS 6 Skull BS, IS 7 Skull, pelvis, C spine BS,CT, IS 8 Ribs BS, X-ray, IS 9 Skull BS, X-ray, IS 10 Skull, pelvis, sternum BS, X-ray, IS 11 L spine X-ray, CT 12 L & S spine BS, X-ray, IS 13 Femur BS, X-ray, IS 14 Sacrum, hip BS, X-ray, IS, CT 15 Skull BS, X-ray, IS 16 Skull, ribs, T & L spine BS, X-ray, IS 17 Pelvis, femur BS, X-ray, IS 18 T-spine CT, IS 19 Skull BS, X-ray, IS 20 Skull, ribs, T & L spine BS, X-ray, IS, CT 21 Skull BS, X-ray, IS 22 Pelvis, T-spine BS, X-ray, FNA 23 Sternum X-ray, IS 24 Skull, pelvis BS, X-ray, CT, IS Patient no.
After gadolinium (Gd) administration there was strong enhancement of the extensive intradural metastases, causing cord compression at multiple levels (Fig.
It is important in this setting to evaluate the safety and postoperative morbidity after resection of liver metastases following the administration of bevacizumab, because it has been shown that anti-vascular endothelial growth factor (VEGF) antibodies may interfere with wound healing and liver regeneration.
These results, as well as findings from osteoporosis treatment studies, have led to several phase III trials in patients with bone metastases where denosumab's efficacy is again being compared with intravenous bisphosphonates.
There is no consensus on the optimal treatment strategy for skeletal muscle metastases and although the options could include radiotherapy, chemotherapy or excision, the outcome remains poor.
Slotman's group expected that PCI would reduce the risk of symptomatic brain metastases, but the results revealing a survival difference in the two groups were not expected.
Rectal carcinoma metastases to the skin usually present as small subcutaneous or intradermal nodules that vary from pink violaceous to brown-black hues.
The DNAX team plans to study whether the antibodies that limit the interactions between chemokines and their receptors have any effect on the growth of metastases after the cancer cells have already spread.
With regard to the number of patients without metastases (FP plus true-negative marker test results), the numbers of individuals shown for specificity vary among the three columns in Table 1, not because of different cutoff values but because of the procedure used to calculate data for specificity.
The purpose of the Phase 2 study is to assess the efficacy, safety and tolerability of GRN1005 in patients with brain metastases from breast cancer.