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Related to Metastatic disease: multiple myeloma, myeloma, metastases


1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
To get a clearer picture of the prevalence of advanced breast cancer in the United States, they worked backward from Surveillance, Epidemiology, and End Results data on breast cancer deaths and survival, working on the assumption that each observed breast cancer death is the result of metastatic disease, either in women whose initial diagnosis was stage IV disease (de novo metastatic disease) or disease recurrence with metastases.
Symptoms due to metastatic disease to the pituitary are protean.
Within the 10-year post-treatment follow-up period, 13% (224) of all study patients developed metastatic disease.
The entity of the 'bone scan-negative, PET-positive' patient with bony metastatic disease is now clearly recognised, with the lesions virtually always being lytic in this situation.
All patients with metastatic disease are eventually considered for chemotherapy.
Unfortunately, metastatic disease is common in neuroblastoma, often causing symptoms that prompt medical attention.
In one of the newly-published studies, CORTOSS was percutaneously injected into the fractured vertebra of 24 patients with pain related to vertebral fractures caused by osteoporotic and metastatic disease.
In these studies, it was noted that a small but significant number of patients without bone scan evidence of metastatic disease also had increased concentrations of the resorption markers.
PSMA is a protein abundantly expressed on the surface of prostate cancer cells, with an increased expression in high-grade cancers, metastatic disease and hormone-refractory prostate cancer.
Many prostate cancer patients who initiate androgen deprivation therapy will experience disease progression illustrated by a rising PSA level, and currently, there are no FDA-approved treatment options for patients with non-metastatic CRPC until they develop confirmed radiographic metastatic disease, said Neal Shore, M.
18 February 2014 - US molecular diagnostic company Myriad Genetics Inc (NASDAQ:MYGN) unveiled today study findings showing that its Prolaris prognostic test is able to accurately predict, based on biopsy specimens, which men would develop biochemical recurrence (BCR) or metastatic disease after radical prostate surgery.
In the multivariate analysis, screening era, T stage, and biopsy Gleason score remained statistically significant predictors of metastatic disease.

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