(redirected from Metastatic disease)
Also found in: Dictionary, Thesaurus, Medical, Legal.
Related to Metastatic disease: multiple myeloma, myeloma, metastases


1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
5 years following detection of metastatic disease in the breast (12), and the 1-year survival rate has been reported at 40% (13).
This has most to do with widespread metastatic disease at the time of diagnosis rather than pituitary involvement.
In a univariate analysis, screening era, age, T stage, pretreatment PSA value, and Gleason score on biopsy were significantly associated with the development of metastatic disease (P less than .
As well as resulting in false-positive results in the context of degenerative change, trauma, inflammation and infection, it is not sensitive for the detection of lytic metastatic disease.
When metastatic disease has been confirmed, it is essential to discuss prognosis and expectations with the patient and her family.
Orbital metastatic disease usually presents as a mass in the extraconal space with resultant proptosis.
The most common causes of vertebral compression fractures are osteoporosis associated with aging or chronic steroid use and metastatic disease.
Although there has been uncertainty about the meaning of central abdominal activity on these scans, most physicians experienced in the use of PROSTASCINT believe that this multifocal abdominal pattern represents metastatic disease in retroperitoneal and/or mesenteric lymph nodes," said Michael Manyak, M.
a highly validated genomic test for predicting metastatic disease in men with prostate cancer.
Eight patients in the dendritic cell vaccine study experienced remarkable long-term, progression-free survival after completing the vaccine therapy, even though they had widely metastatic disease and/or repeated appearance of new metastases despite various therapies.
For metastatic disease to the lungs, abdomen, and neck, she was treated with chemotherapy, and she achieved a complete response.
One patient with Paget's disease died from metastatic disease (6%) compared to nine patients with nipple carcinoma who died from metastatic disease (26%).

Full browser ?