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The presence of methemoglobin in the blood.



the appearance of methemoglobin in the blood as a result of the toxic effect of various chemical substances (nitrates and nitrites, aniline, pyridine) that are capable of converting hemoglobin to methemoglobin (MtHb) upon entering the body through the skin, digestive tract, or lungs. With considerable methemoglobinemia, oxygen starvation, or hypoxia, may result. Methemoglobin may be excreted with the urine (methemoglobinuria); this is sometimes damaging to the kidneys. Methemoglobinemia is treated with antidotes (methylene blue, ascorbic acid) and oxygen therapy.

References in periodicals archive ?
25 November 2011 - Japanese pharmaceutical company Daiichi Sankyo Co Ltd (TYO:4568) said Friday it has signed a licence agreement for the development of Methylthioninium chloride solution for injection from French Provepharm SAS, for the treatment of life-threatening medicinal and chemical products induced methaemoglobinaemia in Japan.
Acute DDS poisoning is potentially lethal due to severe methaemoglobinaemia and haemolytic anaemia.
Influence of Edwardsiella ictaluri septicemia on nitrite-induced methaemoglobinaemia in channel catfish (Ictalurus punctatus).
Methaemoglobinaemia mainly poses a risk to bottle fed infants, mostly below 3 months of age.
This can cause methaemoglobinaemia or act as precursor in the endogenous formation of carcinogenic nitrosamines.
The present study aimed to explore the extent of methaemoglobinaemia in cardiac patients receiving nitrate therapy.
Methylene blue: A treatment for severe methaemoglobinaemia secondary to misuse of amyl nitrite.
Nitrate in drinking water can cause methaemoglobinaemia in infants, which has been reported from several countries.
Experts said the pair were "very lucky" to have survived after contracting methaemoglobinaemia, which is linked to bingeing on cocaine.