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The presence of methemoglobin in the blood.



the appearance of methemoglobin in the blood as a result of the toxic effect of various chemical substances (nitrates and nitrites, aniline, pyridine) that are capable of converting hemoglobin to methemoglobin (MtHb) upon entering the body through the skin, digestive tract, or lungs. With considerable methemoglobinemia, oxygen starvation, or hypoxia, may result. Methemoglobin may be excreted with the urine (methemoglobinuria); this is sometimes damaging to the kidneys. Methemoglobinemia is treated with antidotes (methylene blue, ascorbic acid) and oxygen therapy.

References in periodicals archive ?
ANI's first half 2015 results yielded material increases in revenue, EBITDA, operating income, and earnings per share over the prior year period, due primarily to our acquisitions of Lithobid and Vancocin as well as the launch of Methazolamide tablets, Etodolac capsules and Propafenone tablets, three of the generic products we acquired in 2014.
Long-term administration of methazolamide is contraindicated in patients with angle-closure glaucoma, since organic closure of the angle may occur in spite of lowered intraocular pressure.
1 million in the prior period, primarily due to increased sales of EEMT, as well as sales from its Methazolamide and Etodolac products, which were launched in the fourth quarter of 2014 and the first quarter of 2015, respectively.
In the fourth quarter we also launched Vancocin under our own ANI label and the first of our products acquired from Teva, Methazolamide.
ANI") (NASDAQ: ANIP) today announced the launch of Methazolamide USP 25mg and 50mg oral tablets, indicated for the treatment of ocular conditions.
DUBLIN, March 12, 2014 /PRNewswire/ -- Perrigo Company (NYSE: PRGO; TASE) today announced that it has launched, through a distribution and supply agreement, methazolamide tablets, the generic equivalent to Neptazane(TM) tablets.