Methemoglobinemia


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Related to Methemoglobinemia: Blue baby syndrome

methemoglobinemia

[¦met‚hē·mə·glō·bə′nē·mē·ə]
(medicine)
The presence of methemoglobin in the blood.

Methemoglobinemia

 

the appearance of methemoglobin in the blood as a result of the toxic effect of various chemical substances (nitrates and nitrites, aniline, pyridine) that are capable of converting hemoglobin to methemoglobin (MtHb) upon entering the body through the skin, digestive tract, or lungs. With considerable methemoglobinemia, oxygen starvation, or hypoxia, may result. Methemoglobin may be excreted with the urine (methemoglobinuria); this is sometimes damaging to the kidneys. Methemoglobinemia is treated with antidotes (methylene blue, ascorbic acid) and oxygen therapy.

References in periodicals archive ?
Phenazopyridine should be used with caution especially for an infant younger than 1 month or with G6PD deficiency because of the risk for methemoglobinemia, sulfhemoglobinemia, and hemolytic anemia.
Methylene blue is used to treat methemoglobinemia, and hematin and carotene derivatives are used to treat porphyrias.
poisoning may cause methemoglobinemia is dictated by the capacity of the
To manage his methemoglobinemia, he was given 80mg of methylene blue 1% (1-2mg/kg as recommended by British National Formulary (7)) intravenously over 10 minutes, after which his oxygen saturation (measured via the pulse oximetry) increased gradually to almost match that measured by ABG analysis [Figure 1].
The signs and symptoms of methemoglobinemia vary depending on the fraction of methemoglobin.
Toxic methemoglobinemia is a toxic disorder in which the methemoglobin concentration in the blood is elevated due to various substances found in drugs, pesticides, etc.
Newborn organisms are very sensitive to methemoglobinemia because they have an immature "methemoglobin reductase system" [5].
However, nitrite, an intermediate of nitrate reduction, carries the risk of toxicity and causing methemoglobinemia (Zhou et al.
Prilocaine and lidocaine are classified as amide- type local anesthetics for which serious adverse effects include methemoglobinemia.
htm) about methemoglobinemia, which is a rare but life-threatening medical condition that develops when a child has been exposed to benzocaine medication for some time.