Methylation capacity definition of Methylation capacity in the Free Online Encyclopedia.

methylation [‚meth·ə′lā·shən]

(organic chemistry)

A chemical process for introducing a methyl group (CH₃‒) into an organic compound.

Methylation

the replacement of a hydrogen, metal, or halogen atom by a methyl group,—CHs; it is effected by the action of various methylating agents—for example, methyl iodide, CH₃I; dimethyl sulfate, (CH₃O)₂SO₂; methylsulfuric acid, CH₃OSO₃H; methyl esters of organic sulfo acids; methanol, CHjOH; and dimethyl ether, (CH₃)₂O. Methylation is widely used in organic synthesis in industry. For example, methylation with dimethyl sulfate is used in the synthesis of pharmaceuticals (for example, metapyrin); amidopyrine is prepared by methylation with formaldehyde and a reducing agent, usually formic acid.

Aromatic hydrocarbons are readily methylated by the action of methyl chloride or dimethyl ether in the presence of AlCl₃. Methylaniline and dimethylaniline are prepared industrially by methylation of aniline with methanol over A1₂O₃ at high temperatures:

Methylation with diazomethane is widely used to produce methyl esters of carboxylic acids under laboratory conditions, according to the formula

R—COOH + CH₂N₂→RCOOCH₃ + N₂

B. L. DIATKIN

Mentioned in	?		References in periodicals archive	?		Encyclopedia browser	?		Full browser	?
No references found	Women had significantly lower percentages of As in urine present as MMA (%MMA) and higher as DMA (%DMA), suggesting a higher As methylation capacity in women for the second methylation step (Table 2). Influence of cobalamin on arsenic metabolism in Bangladesh by Hall, Megan N.; Liu, Xinhua; Slavkovich, Vesna; llievski, Vesna; Mi, Zhongyuan; Alam, Shafiul; Facto / Environmental Health Perspectives The less severely mutated embryos might rally their remaining methylation capacity to secure adequate methylation of the Igf-2 receptor gene, while somehow deeming other genes less important, he speculates. Embryo uses chemistry to tell genes apart by Strobel, Gabrielle / Science News The influence of the M287T (T[right arrow]C) polymorphism in the AS3MT gene on the methylation capacity was much more pronounced in men than in women. Metabolism of low-dose inorganic arsenic in a central european ... by Lindberg, Anna-Lena; Kumar, Rajiv; Goessler, Walter; Thirumaran, Ranjit; Gurzau, Eugen; Koppova, Kve / Environmental Health Perspectives	methyl propyl carbinol methyl red methyl red test methyl ricinoleate methyl salicylate methyl silicone methyl stearate methyl styrene methyl sulfate methyl sulfide methyl tertiary butyl ether methyl tetradecanoate methyl transferase methyl violet methyl-n-amyl ketone methyl-N-carbamate methylacetic acid methylal Methylamine methylarsinic sulfide methylate methylated cap methylated spirit methylated spirits Methylation Methylation capacity methylbenzene methylbenzethonium chloride methylbutynol methylcellulose methylcyclopentadiene dimer Methyldichlorarsine methyldichlorosilane methylene Methylene Blue methylene bromide Methylene Chloride methylene iodide methylene oxide methylene succinic acid Methylene-Urea Fertilizers methylethylcellulose methylheptenone methylidyne methylisothiocyanate methylmercury compound methylmercury cyanide methylmercury nitrile methylnaphthalene methylol riboflavin methylol urea	Methylaniline methylarsinic sulfide methylases methylate methylate methylate methylated methylated methylated Methylated Bovine Serum Albumin methylated cap Methylated Quaternary Ammonium Compound Methylated Seed Oil methylated spirit methylated spirit methylated spirit Methylated spirits Methylated spirits Methylated spirits Methylated spirits Methylated-Hydrogen Silsesquoxane methylates methylates methylates methylating methylating methylating methylation methylation methylation Methylation capacity Methylation Sensitive DNA Binding Protein Methylation testing Methylation-Dependent Binding Protein Methylation-Sensitive Amplification Polymorphism Methylation-Specific Digital Karyotyping Methylation-Specific PCR methylations methylations methylations methylator methylator methylator methylatropine methylazoxymethanol methylbenzene methylbenzene methylbenzene methylbenzethonium methylbenzethonium chloride methylbenzethonium chloride Methylbutane methylbutynol methylcellulose methylcellulose methylcellulose Methylcholanthrene Methylcholanthrene Methylcobalamin Methylcobalamin Methylcobalamin

Mentioned in

References in periodicals archive

Encyclopedia browser

Full browser

No references found

Women had significantly lower percentages of As in urine present as MMA (%MMA) and higher as DMA (%DMA), suggesting a higher As methylation capacity in women for the second methylation step (Table 2).

Influence of cobalamin on arsenic metabolism in Bangladesh by Hall, Megan N.; Liu, Xinhua; Slavkovich, Vesna; llievski, Vesna; Mi, Zhongyuan; Alam, Shafiul; Facto / Environmental Health Perspectives

The less severely mutated embryos might rally their remaining methylation capacity to secure adequate methylation of the Igf-2 receptor gene, while somehow deeming other genes less important, he speculates.

Embryo uses chemistry to tell genes apart by Strobel, Gabrielle / Science News

The influence of the M287T (T[right arrow]C) polymorphism in the AS3MT gene on the methylation capacity was much more pronounced in men than in women.

Metabolism of low-dose inorganic arsenic in a central european ... by Lindberg, Anna-Lena; Kumar, Rajiv; Goessler, Walter; Thirumaran, Ranjit; Gurzau, Eugen; Koppova, Kve / Environmental Health Perspectives

methyl propyl carbinol

methyl tertiary butyl ether